NCT00291109已完成不适用
Quantitative Real Time PCR in Cytolytic Formalin Fixed Breast Cells Obtained by Periareolar Fine Needle Aspiration. An Ancillary Protocol to a Chemoprevention Trial of Letrozole
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
研究概览
简要总结
To assess the quantitative real time PCR results of oligonucleotide probes for a number of gene transcription products that may be useful as predictors or indicators of response to letrozole
详细描述
To assess the quantitative real time PCR results of oligonucleotide probes for a number of gene transcription products (PCNA, cyclin-D1, ER alpha, PR, pS2, 450 aromatase, bcl-2, bax, caspase-3, and VEGFR) that may be useful as predictors or indicators of response to letrozole
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •evidence of hyperplasia with/without atypia upon random periareolar fine needle aspiration of breast
- •on hormone replacement therapy
- •postmenopausal
- •increased risk of developing breast cancer based on personal or family history
- •never have taken aromatase inhibitors or selective estrogen receptor modulators in last six months
- •women who have a high risk of breast cancer
- •older than 18 years
排除标准
- •no anticoagulants
- •no marked breast tenderness
- •not pregnant or within twelve months of breast feeding/childbirth
研究者
研究点 (1)
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