ABTECT-1 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -1
- Registration Number
- NCT05507203
- Lead Sponsor
- Abivax S.A.
- Brief Summary
This is a multicenter, randomized, placebo controlled study to evaluate the efficacy and safety of ABX464 given at 25 or 50 mg QD in inducing clinical remission in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhibitors, anti-integrins, anti-IL-23), and/or S1P receptor modulators, and/or JAK inhibitors\].
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 612
- Men or women at least 16 years old; Adolescent subjects will only be enrolled if approved by the country regulatory/health authority. If these approvals have not been granted, only subjects ≥ 18 years old will be enrolled. To be eligible, adolescent subjects must weight ≥ 40 kg and meet the definition of Tanner Stage 5 at the screening visit.
- Subjects must understand, sign and date the written voluntary informed consent form at the visit prior to any protocol-specific procedures. For under-aged subjects, national requirements regarding consent should also be met.
- Documented diagnosis of UC confirmed by endoscopy and histology. Should endoscopy/histology results not be available at screening, results from endoscopies or biopsies taken at screening may be used.
- Active disease defined by modified Mayo score (MMS) ≥ 5 with rectal bleeding subscore (RBS) ≥ 1 and endoscopy subscore (MES) of 2 or 3 (confirmed by central reader).
- Subjects with documented inadequate response (defined as lack of response or loss of response or intolerance) to at least one of the following treatments: corticosteroids, immunosuppressant, biologic or biosimilar therapies, S1P receptor modulators and/or JAK inhibitors and/or new drugs approved during the study (note: failure to only 5-ASA or sulfasalazine is not accepted).
- Women of childbearing potential (WOCBP) subjects and male subjects with WOCBP partner must agree to comply with the contraception requirements described in the protocol.
- Subjects able and willing to comply with study visits and procedures as per protocol.
- Subjects should be affiliated to a health insurance policy whenever required by a participating country or state.
-
Subjects with UC limited to an isolated proctitis (≤ 15cm from anal verge) determined by endoscopy central reading.
-
Subjects with primary sclerosing cholangitis or autoimmune hepatitis.
-
Subjects who have failed on 5-ASA or sulfasalazine therapy only.
-
Subjects with CD or presence or history of fistula, indeterminate colitis, infectious/ischemic colitis or microscopic colitis (lymphocytic and collagenous colitis).
-
History or current evidence of toxic megacolon, fulminant colitis, bowel perforation.
-
History of colonic cancer or colonic low grade or high grade dysplasia adenomatous polyps, and/or at the screening endoscopy, evidence of colonic cancer or evidence of low grade or high grade dysplasia adenomatous polyps (fully removed or not).
-
Recent or planned bowel surgery or history of proctocolectomy or partial colectomy or current stoma.
-
Subjects on antidiarrheals including those working on motility (e.g., loperamide, diphenoxylate with atropine, etc.).
-
Subjects on probiotics (e.g., Culturelle® [Lactobacillus GG, i-Health, Inc.], Saccharomyces boulardii).
-
Subjects who do not meet the washout period requirements prior to the screening endoscopy
-
Subjects with the following hematological and biochemical laboratory parameters obtained during the screening period:
- Hemoglobin ≤ 8.0 g dL-1
- Absolute neutrophil count < 750 mm-3
- Platelets < 100,000 mm-3
- Creatinine clearance < 60 mL.min-1 (Cockroft-Gault formula)
- Total serum bilirubin > 1.5 x ULN
- Alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) > 2 x ULN
-
Subjects with the following conditions (infection):
- Subjects with chronic or recurrent grade 3 or grade 4 infection within the last 2 months prior to screening or a history of opportunistic infection while not on immunosuppressive therapy.
- Herpes zoster reactivation within the last 2 months prior to screening.
- Subjects with active infection at screening or any major episode of infection that required hospitalization or treatment with intravenous antibiotics within 1 month of screening or during screening. Fungal infection of nail beds is allowed.
- Positive assay or stool culture for pathogens (ova and parasite examination, bacteria) or positive test for Clostridium difficile toxin at screening. If C. difficile is positive, subject may be treated and retested ≥ 2 weeks after completing treatment.
- Subjects with HIV infection.
- Subjects having acute or chronic hepatitis B infection at screening (positive for hepatitis B surface antigen [HbsAg], or negative for HbsAg and positive for anti-hepatitis B core antibody in conjunction with detectable HBV DNA, or detectable HBV DNA).
- Subjects having acute or chronic hepatitis C infection at screening as defined by positive for hepatitis C antibody (subjects successfully treated and without recurrence ≥ 1 year with no detectable HCV RNA [assessed centrally] are eligible).
- Active tuberculosis (TB) or untreated latent TB are ruled out. For subjects with positive or intermediate QuantiFERON test see study protocol.
-
Subjects with an uncontrolled ischemic heart disease and/or a history of congestive heart failure with New York Heart Association (NYHA) class 3 or 4 symptoms.
-
Subjects with a family or personal history of congenital or acquired long QT syndrome, or subjects with a marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTc interval [Fridericia or Bazett correction] >450 milliseconds for male and > 460 milliseconds for female).
-
Subjects with a history of torsade de pointe (TdP).
-
Acute or chronic of clinically relevant pulmonary, hepatic, pancreatic or renal functional abnormality, encephalopathy, neuropathy or unstable central nervous system pathology such as seizure disorder, or any other clinically significant medical problems as determined by physical examination and/or laboratory screening tests and/or medical history (note: treated autoimmune hypothyroidy and autoimmune diabetes are allowed).
-
Serious illness requiring hospitalization within 4 weeks prior to screening (except UC flare).
-
Subjects previously treated with ABX464.
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Subjects with a known hypersensitivity to the active substance or to any of the excipients.
-
WOCBP subject who is pregnant or breast-feeding at screening, or intends to become pregnant during the study, or male subject with WOCBP partner who intends to be pregnant during the study.
-
Illicit drug or alcohol abuse or dependence.
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Subjects who received live vaccine within 3 months prior to screening and/or who's planning to receive such a vaccine during the study duration.
-
Use of any investigational or non-registered product within 3 months or within 5 half-lives preceding baseline, whichever is longer, and during the study.
-
Subjects committed to an institution by virtue of an order issued either by the judicial or the administrative authorities.
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Any condition, which in the opinion of the investigator, could compromise the subject's safety or adherence to the study protocol.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description ABX464 50mg ABX464 Subjects will be orally dosed daily in a fed condition ideally at the same time in the morning) for 8 weeks Placebo Placebo Subjects will be orally dosed daily in a fed condition ideally at the same time in the morning) for 8 weeks ABX464 25mg ABX464 Subjects will be orally dosed daily in a fed condition ideally at the same time in the morning) for 8 weeks
- Primary Outcome Measures
Name Time Method Proportion of subjects who achieve clinical remission per Modified Mayo Score at week 8 8 weeks To compare the efficacy of ABX464 versus placebo on clinical remission
- Secondary Outcome Measures
Name Time Method Proportion of subjects who achieve clinical response per MMS at week 8 8 weeks To compare the efficacy of ABX464 versus placebo on clinical response as per MMS
Proportion of subjects who achieve endoscopic improvement at week 8 8 weeks To compare the efficacy of ABX464 versus placebo on endoscopic improvement
Proportion of subjects with HEMI per Geboes at week 8 8 weeks To compare the efficacy of ABX464 versus placebo on histologic-endoscopic mucosal
Proportion of subjects with symptomatic remission at week 8 8 weeks To compare the efficacy of ABX464 versus placebo on symptomatic remission
Trial Locations
- Locations (248)
Boston Medical Center
🇺🇸Boston, Massachusetts, United States
Biopharma Informatic, LLC
🇺🇸Houston, Texas, United States
MedOne Clinical Research LLC
🇺🇸Miami, Florida, United States
Indiana University School of Medicine
🇺🇸Indianapolis, Indiana, United States
University of Kansas Medical Center Research Institute, Inc.
🇺🇸Kansas City, Kansas, United States
Peak Gastroenterology Associates
🇺🇸Colorado Springs, Colorado, United States
AGA Clinical Research Associates, LLC
🇺🇸Egg Harbor Township, New Jersey, United States
LKH - Universitätsklinikum der PMU Salzburg
🇦🇹Salzburg, Austria
Medicana Kadikoy Hospital
🇹🇷Istanbul, Turkey
Footscray Hospital
🇦🇺Footscray, Victoria, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Semmelweis Egyetem
🇭🇺Budapest, Hungary
LKH - Universitaetsklinikum Graz
🇦🇹Graz, Austria
Medizinische Universität Innsbruck
🇦🇹Innsbruck, Austria
University of Arkansas for Medical Sciences
🇺🇸Little Rock, Arkansas, United States
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Austin Health
🇦🇺Heidelberg, Victoria, Australia
Fortis Memorial Research Institute
🇮🇳Gurgaon, Haryana, India
KH der Barmherzigen Brüder St.Veit an der Glan
🇦🇹St Veit an der Glan, Austria
AZ Klina
🇧🇪Brasschaat, Belgium
AZ Sint-Lucas
🇧🇪Brugge, Belgium
Clinique CHC MontLégia
🇧🇪Liège, Belgium
UMHAT 'Tsaritsa Yoanna - ISUL', EAD
🇧🇬Sofia, Bulgaria
UMHAT Prof. Dr. Stoyan Kirkovich AD
🇧🇬Stara Zagora, Bulgaria
CHU Besançon - Hôpital Jean Minjoz
🇫🇷Besançon, Doubs, France
Twoja Przychodnia-Szczecinskie Centrum Medyczne Sp. z o. o.
🇵🇱Szczecin, Poland
CHU UCL Namur
🇧🇪Yvoir, Belgium
DCC "Alexandrovska", EOOD
🇧🇬Sofia, Bulgaria
M. S. Ramaiah Medical College and Hospital
🇮🇳Bangalore, Karnataka, India
NZOZ Centrum Medyczne ProMiMed
🇵🇱Kraków, Poland
Centrum Medyczne Oporow
🇵🇱Wrocław, Poland
Gastroenterology Center of the MidSouth PC
🇺🇸Germantown, Tennessee, United States
Box Hill Hospital
🇦🇺Box Hill, Victoria, Australia
Bernhoven Uden
🇳🇱Uden, Netherlands
Yeovil District Hospital
🇬🇧Yeovil, Somerset, United Kingdom
Chopda Medicare & Research Centre
🇮🇳Nashik, Maharashtra, India
Dayanand Medical College and Hospital
🇮🇳Ludhiāna, Punjab, India
K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre
🇮🇳Belagave, Karnataka, India
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
University of Utah
🇺🇸Salt Lake City, Utah, United States
Lakeview Clinical Research
🇺🇸Guntersville, Alabama, United States
GI Alliance
🇺🇸Gurnee, Illinois, United States
Del Sol Research Management, LLC
🇺🇸Tucson, Arizona, United States
California Medical Research Associates Inc.
🇺🇸Northridge, California, United States
Gastro Care Institute
🇺🇸Lancaster, California, United States
Aurora Care Clinic
🇺🇸Costa Mesa, California, United States
Access Research Institute
🇺🇸Brooksville, Florida, United States
Clinnova Research Solutions
🇺🇸Orange, California, United States
Auzmer Research
🇺🇸Lakeland, Florida, United States
Cfagi, Llc
🇺🇸Maitland, Florida, United States
Medical Professional Clinical Research Center
🇺🇸Miami, Florida, United States
Digestive Healthcare of Georgia
🇺🇸Atlanta, Georgia, United States
Eagle Clinical Research
🇺🇸Chicago, Illinois, United States
Gastroenterology Associates of Pensacola, PA
🇺🇸Pensacola, Florida, United States
One Health Research Clinic Atlanta, LLC
🇺🇸Norcross, Georgia, United States
Lucida Clinical Trials LLC
🇺🇸New Bedford, Massachusetts, United States
Digestive Health Center PA
🇺🇸Ocean Springs, Mississippi, United States
GI Alliance - Baton Rouge
🇺🇸Baton Rouge, Louisiana, United States
Columbia Digestive Health Research
🇺🇸Columbia, South Carolina, United States
Gastro Health Research
🇺🇸Cincinnati, Ohio, United States
DSI Research LLC
🇺🇸Springboro, Ohio, United States
Care Access Research Lumberton
🇺🇸Lumberton, North Carolina, United States
Wexner Medical Center
🇺🇸Columbus, Ohio, United States
Wilmington Health
🇺🇸Wilmington, North Carolina, United States
Gastroenterology Associates, PA
🇺🇸Greenville, South Carolina, United States
Central Texas Clinical Research, LLC
🇺🇸Austin, Texas, United States
Cook Children's Medical Center
🇺🇸Fort Worth, Texas, United States
Texas Digestive Disease Consultants
🇺🇸Cedar Park, Texas, United States
GI Alliance - Southlake
🇺🇸Austin, Texas, United States
Baylor Scott and White
🇺🇸Dallas, Texas, United States
Biopharma Informatic, Inc. Research Center
🇺🇸Houston, Texas, United States
Gastro Health & Nutrition
🇺🇸Katy, Texas, United States
Texas Gastroenterology Associates
🇺🇸Spring, Texas, United States
GI Alliance - Webster
🇺🇸Webster, Texas, United States
Care Access Research LLC
🇺🇸Ogden, Utah, United States
TPMG Clinical Research Williamsburg
🇺🇸Williamsburg, Virginia, United States
Hospital Italiano de Buenos Aires
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
STAT Research S.A.
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Blacktown Hospital
🇦🇺Blacktown, New South Wales, Australia
Coral Sea Clinical Research Institute
🇦🇺North Mackay, Queensland, Australia
St Vincent's Hospital Melbourne
🇦🇺Fitzroy, Victoria, Australia
C. H. U. St-Pierre
🇧🇪Bruxelles, Belgium
Universitair Ziekenhuis Brussel
🇧🇪Bruxelles, Belgium
UZ Leuven
🇧🇪Leuven, Belgium
Medical center Medconsult Pleven OOD
🇧🇬Pleven, Bulgaria
UMHATEM 'N.I. Pirogov', EAD
🇧🇬Sofia, Bulgaria
The First Affiliated Hospital of Bengbu Medical College
🇨🇳Bengbu, Anhui, China
Kensington Screening Clinic
🇨🇦Toronto, Ontario, Canada
Beijing Friendship Hospital, Capital Medical University
🇨🇳Beijing, Beijing, China
Scott Shulman Medicine Professional Corporation
🇨🇦North Bay, Ontario, Canada
Yijishan Hospital of Wannan Medical College
🇨🇳Wuhu, Anhui, China
Xiangya Hospital, Central South University
🇨🇳Changsha, Hunan, China
The First Affiliated Hospital of Sun Yat-sen University
🇨🇳Guangzhou, Guangdong, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
The People's Hospital of Guangxi Zhuang Autonomous Region
🇨🇳Nanning, Guangxi, China
The 2nd Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
Changzhou No.2 People's Hospital
🇨🇳Changzhou, Jiangsu, China
General Hospital of Eastern Theater Command
🇨🇳Nanjing, Jiangsu, China
Jiangxi Gannan Medical College Affiliated 1 st Hospital
🇨🇳Ganzhou, Jiangxi, China
Binzhou Medical University Hospital
🇨🇳Binzhou, Shandong, China
The Second Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
Jinan Central Hospital
🇨🇳Jinan, Shandong, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Shanghai General Hospital
🇨🇳Shanghai, Shanghai, China
SurGal Clinic s.r.o.
🇨🇿Brno, Czechia
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
PreventaMed s.r.o.
🇨🇿Olomouc, Czechia
CCR Ostrava s.r.o.
🇨🇿Ostrava, Czechia
Nemocnice Slany
🇨🇿Slaný, Czechia
CHU Reims - Hôpital Robert Debré
🇫🇷Reims, Ardennes, France
CHU Dijon - Hôpital Bocage Central
🇫🇷Dijon, Cote D'or, France
CHU Bordeaux - Hôpital Haut-Lévêque
🇫🇷Pessac, Gironde, France
Hopital Saint Eloi
🇫🇷Montpellier, Herault, France
CHU Nantes - Hôtel Dieu
🇫🇷Nantes, Loire Atlantique, France
CHU Clermont Ferrand - Hopital d'Estaing
🇫🇷Clermont-Ferrand, Puy De Dome, France
Centre Hospitalier de Pau - Hôpital François Mitterrand
🇫🇷Pau, Pyrénées Atlantique, France
Hôpital Henri Mondor
🇫🇷Créteil, Val De Marne, France
Hôpital Bicêtre
🇫🇷Le Kremlin-Bicêtre, Val De Marne, France
Hôpital Saint-Louis
🇫🇷Paris, France
Praxis fuer Gasroenterologie Prof. Dr. med Robert Ehehalt
🇩🇪Heidelberg, Baden Wuerttemberg, Germany
University General Hospital of Alexandroupolis
🇬🇷Alexandroupolis, Greece
Charité - Campus Benjamin Franklin
🇩🇪Berlin, Germany
General Hospital of Athens "Evangelismos"
🇬🇷Athens, Greece
Corfu General Hospital "St. Eirini"
🇬🇷Corfu, Greece
University General Hospital of Heraklion
🇬🇷Heraklion, Greece
General Hospital of Thessaloniki "Hippokration"
🇬🇷Thessaloníki, Greece
Clinexpert Kft.
🇭🇺Budapest, Hungary
Bekes Varmegyei Kozponti Korhaz
🇭🇺Békéscsaba, Hungary
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz
🇭🇺Szombathely, Hungary
Shree Giriraj Multispeciality Hospital
🇮🇳Rājkot, Gujarat, India
Pannonia Maganorvosi Centrum
🇭🇺Budapest, Hungary
Navneet Memorial Hospital 'Sushrusha'
🇮🇳Ahmedabad, Gujarat, India
Unity Hospital ICU and Trauma
🇮🇳Sūrat, Gujarat, India
King Edward Memorial Hospital Research Centre
🇮🇳Mumbai, Maharashtra, India
Amrita Institute Of Medical Sciences and Research Centre
🇮🇳Cochin, Kerala, India
Midas Multispeciality Hospital Pvt Ltd
🇮🇳Nagpur, Maharashtra, India
IRCCS Ospedale Casa Sollievo della Sofferenza
🇮🇹San Giovanni Rotondo, Foggia, Italy
Ospedale Sacro Cuore Don Calabria
🇮🇹Negrar, Verona, Italy
Fondazione Poliambulanza Istituto Ospedaliero
🇮🇹Brescia, Italy
Presidio Ospedaliero Garibaldi Nesima
🇮🇹Catania, Italy
Ospedale San Raffaele
🇮🇹Milano, Italy
Azienda Ospedaliera Ospedali Riuniti "Villa Sofia-Cervello"
🇮🇹Palermo, Italy
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico
🇮🇹Milano, Italy
Fondazione IRCCS Policlinico San Matteo
🇮🇹Pavia, Italy
Ospedale San Bortolo di Vicenza
🇮🇹Vicenza, Italy
Seoul National University Bundang Hospital
🇰🇷Seongnam, Gyeonggi-do, Korea, Republic of
Korea University Ansan Hospital
🇰🇷Ansan-si, Gyeonggi-do, Korea, Republic of
CHA Bundang Medical Center, CHA University
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
The Catholic University of Korea, Daejeon St. Mary's Hospital
🇰🇷Daejeon, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Radboud UMC
🇳🇱Nijmegen, Netherlands
Zuyderland Medisch Centrum - Sittard-Geleen
🇳🇱Sittard, Netherlands
ETZ Elisabeth
🇳🇱Tilburg, Netherlands
Przychodnia Specjalistyczna Insula
🇵🇱Belchatow, Poland
Szpital Zakonu Bonifratow Sp. z o.o.
🇵🇱Katowice, Poland
Centrum Medyczne PROMED
🇵🇱Kraków, Poland
Kiepury Clinic MAŁGORZATA JARNOT SPECJALISTYCZNA PRAKTYKA GINEKOLOGICZNO-POŁOŻNICZA
🇵🇱Sosnowiec, Poland
Centrum Zdrowia MDM
🇵🇱Warsaw, Poland
Twoja Przychodnia Opolskie Centrum Medyczne
🇵🇱Opole, Poland
SOLUMED Centrum Medyczne
🇵🇱Poznań, Poland
Twoja Przychodnia PCM
🇵🇱Poznań, Poland
ETG Zamosc
🇵🇱Zamość, Poland
AMICARE spółka z ograniczoną odpowiedzialnością spółka komandytowa
🇵🇱Łódź, Poland
NSZOZ Termedica - Centrum Badan Klinicznych
🇵🇱Poznań, Poland
NZOZ VIVAMED Jadwiga Miecz
🇵🇱Warszawa, Poland
PlanetMed sp. z o.o.
🇵🇱Wrocław, Poland
Hospital de Braga
🇵🇹Braga, Portugal
Hospital da Senhora da Oliveira Guimarães
🇵🇹Guimarães, Portugal
Hospital Universitario Reina Sofia
🇪🇸Córdoba, Cordoba, Spain
Hospital General Universitario Gregorio Marañon
🇪🇸Madrid, Spain
Centro Hospitalar do Alto Minho - Unidade Local de Saúde do Alto Minho, EPE
🇵🇹Viana Do Castelo, Portugal
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Hospital Universitari i Politecnic La Fe
🇪🇸Valencia, Spain
Inselspital - Universitaetsspital Bern
🇨🇭Bern, Switzerland
Intesto Gastroenterologische Praxis, Crohn-Colitis-Zentrum Bern
🇨🇭Bern, Switzerland
Universitaetsspital Zuerich
🇨🇭Zuerich, Switzerland
Hammersmith Hospital
🇬🇧London, Greater London, United Kingdom
Koc University Hospital
🇹🇷Istanbul, Turkey
Mersin University Medical Faculty
🇹🇷Mersin, Turkey
St Mark's Hospital
🇬🇧Harrow, Middlesex, United Kingdom
Bury Care Organisation
🇬🇧Bury, Greater Manchester, United Kingdom
Huddersfield Royal Infirmary
🇬🇧Huddersfield, West Yorkshire, United Kingdom
The Ulster Hospital
🇬🇧Belfast, United Kingdom
Yonsei University Wonju Severance Christian Hospital
🇰🇷Wŏnju, Gangwon-do, Korea, Republic of
Digestive Health Specialists of the Southeast
🇺🇸Dothan, Alabama, United States
Clinical Research Of Brandon, LLC
🇺🇸Brandon, Florida, United States
Royal Brisbane and Women's Hospital
🇦🇺Herston, Queensland, Australia
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
The Catholic University of Korea, Seoul St. Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Theia Clinical Research Centers, LLC
🇺🇸Temple Terrace, Florida, United States
Atlanta Center for Gastroenterology, P.C.
🇺🇸Decatur, Georgia, United States
Rochester Clinical Research
🇺🇸Rochester, New York, United States
Charlotte Gastroenterology and Hepatology, P.L.L.C
🇺🇸Charlotte, North Carolina, United States
GI Alliance - Garland
🇺🇸Garland, Texas, United States
Houston Methodist Hospital
🇺🇸Houston, Texas, United States
Gastroenterology Associates of Tidewater
🇺🇸Chesapeake, Virginia, United States
Instituto de Investigaciones Clinicas Quilmes
🇦🇷Quilmes, Buenos Aires, Argentina
Blue Ridge Medical Research
🇺🇸Lynchburg, Virginia, United States
GI Alliance - San Marcos
🇺🇸San Marcos, Texas, United States
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Flinders Medical Centre
🇦🇺Bedford Park, South Australia, Australia
The 900th Hospital of The Chinese People's Liberation Army Joint Logistics Support Force
🇨🇳Fuzhou, Fujian, China
The First Affiliated Hospital of Fujian Medical University
🇨🇳Fuzhou, Fujian, China
Nanfang Hospital of Southern Medical University
🇨🇳Guangzhou, Guangdong, China
Qilu Hospital of Shandong University
🇨🇳Jinan, Shandong, China
Taian City Central Hospital
🇨🇳Tai'an, Shandong, China
Army Specialty Medical Center of The Chinese People's Liberation Army
🇨🇳Chongqing, Sichuan, China
CCR Brno, s.r.o.
🇨🇿Brno, Czechia
Hepato-Gastroenterologie HK s.r.o.
🇨🇿Hradec Králové, Czechia
CHU Saint Etienne - Hôpital Nord
🇫🇷Saint-Étienne, Loire, France
Universitaetsklinikum Erlangen
🇩🇪Erlangen, Bayern, Germany
Staedisches Klinikum Brandenburg
🇩🇪Brandenburg an der Havel, Brandenburg, Germany
Universitaetsklinikum Heidelberg
🇩🇪Heidelberg, Baden Wuerttemberg, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Niedersachsen, Germany
Gastroenterologie Berlin Karlshorst
🇩🇪Berlin, Germany
Universitaetsklinikum Frankfurt Goethe-Universitaet
🇩🇪Frankfurt, Hessen, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Kiel
🇩🇪Kiel, Schleswig Holstein, Germany
Kyungpook National University Hospital
🇰🇷Daegu, Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
The Catholic University of Korea, St. Vincent's Hospital
🇰🇷Suwon-si, Gyeonggi-do, Korea, Republic of
Yeungnam University Hospital
🇰🇷Daegu, Gyeongsangbuk-do, Korea, Republic of
Chung-Ang University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Amsterdam UMC, Locatie AMC
🇳🇱Amsterdam, Netherlands
Erasmus MC
🇳🇱Rotterdam, Netherlands
Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lecznej
🇵🇱Łęczna, Poland
Centro Hospitalar de Entre o Douro e Vouga, E.P.E - Hospital de São Sebastião
🇵🇹Santa Maria Da Feira, Portugal
Clinica Gaias - Santiago
🇪🇸Santiago De Compostela, La Coruña, Spain
King's College Hospital
🇬🇧London, Greater London, United Kingdom
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Kocaeli Universitesi Tip Fakultesi
🇹🇷Kocaeli, Turkey
Claraspital
🇨🇭Basel, Switzerland
Advanced Research Institute, Inc.
🇺🇸Orlando, Florida, United States
Endoscopic Research, Inc.
🇺🇸Orlando, Florida, United States
University of Louisville Research Foundation
🇺🇸Louisville, Kentucky, United States
S. R. Kalla Memorial Gastro & General Hospital
🇮🇳Jaipur, Rajasthan, India
Ruby Hall Clinic
🇮🇳Pune, Maharashtra, India
Peking University First Hospital
🇨🇳Beijing, Beijing, China