ISRCTN31812808
Completed
N/A
Myocardial deformation and cardiac remodeling is influenced by obesity - assessment of myocardial strain by CMR feature tracking in healthy obese
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Cardiac remodeling
- Sponsor
- Charité - University Medicine Berlin
- Enrollment
- 170
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Age \>18 and \<60 years
- •2\. BMI \>27 kg/m²
- •3\. No medication except contraceptives or L\-thyroxine
- •4\. Discontinuation of a chronic medication must be medically justifiable because improvement in the condition for which the medication is being taken can be expected through weight loss
Exclusion Criteria
- •1\. Pregnancy/lactation
- •2\. Diseases or functional disorders that, in the opinion of the investigator, preclude participation in a clinical trial
- •3\. Manifest endocrinological or metabolic diseases requiring treatment (diabetes mellitus, hypo\- and hyperthyroidism, Cushing's syndrome, M. Cushing syndrome, Cushing's disease); normal TSH with L\-thyroxine use is acceptable
- •4\. Manifest cardiovascular diseases requiring treatment (hypertension like RR \> 160/95 mmHg or \> two medications; coronary artery disease or previous myocardial infarction; cerebral ischemia or apoplexy; clinically significant diseases of the blood vessels (stenoses of the vessels supplying the brain; renal artery stenoses, pAVK)
- •5\. Diseases of the kidney, liver, or gastrointestinal tract that require treatment and intestinal tract that require chronic medication
- •6\. Significant neurological or psychiatric disorders (depression, epilepsy, schizophrenia, bulimia nervosa)
- •7\. History of bariatric surgery
- •8\. Known or proven abuse of medication, drugs or alcohol
- •9\. Tumor diseases; postoperative phase
- •10\. Acute and chronic infections
Outcomes
Primary Outcomes
Not specified
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