Proteinuria in Deceased Kidney Transplant Donors for Prediction of Chronic Lesions in Pre-Transplant Biopsies – a prospective multi-center study

Recruiting

• Conditions: Z94.0; Kidney transplant status

• Registration Number: DRKS00031008
• Lead Sponsor: Medizinische Universität Wien

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-10
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Harvesting of the donor kidney in Austria
- Allocation of the donor kidney to Austria
- Transplantation of the kidney
- Donor Age =18 years
- Recipient Age =18 years
- Sufficient biomaterial (pre-implant biopsy and donor urine) to perform the pre-defined analyses
- Written informed consent of recipients for assessment of follow-up

Exclusion Criteria

- Withdrawal of consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Association of UPCR with histologically assessed chronic lesion in pre-implant kidney graft biopsies (chronic lesion score) Timing: the BX is done in the operating room before the implantion of the graft; method: punch biopsy, paraffin embedding; standard staining

Secondary Outcome Measures

Name	Time	Method
- Association of UPCR with graft function after transplantation including serum creatinine, estimated glomerular filtration rate, UPCR, graft loss and death<br>- the association of UPCR with chronic lesion of each individual compartment (glomerulosclerosis, arteriosclerosis/arteriolosclerosis, interstitial fibrosis and tubular atrophy)