Brain Attack Surveillance in Corpus Christi--Cognitive (BASIC-Cognitive)

Active, not recruiting

• Conditions: Dementia; Dementia Alzheimers; Dementia, Mixed; Dementia, Vascular
• Interventions: Other: No interventions

• Registration Number: NCT03403257
• Lead Sponsor: University of Michigan

Brief Summary

The Mexican American population in the U.S. is rapidly growing and aging. This project seeks to determine the prevalence and outcomes of cognitive impairment and dementia in Mexican Americans. It also seeks solutions to help patients with cognitive impairment and dementia and their caregivers get the resources they need.

Detailed Description

Hispanic/Latinos will comprise more than 30% of the U.S. population by mid-century, and Mexican Americans account for the largest share of this growing segment of society. This proposal aims to use door-to-door surveillance in Nueces County, Texas, a non-immigrant, bi-ethnic community, to determine the prevalence and trajectory over time of cognitive impairment and dementia in Mexican Americans and non Hispanic whites. The study will elucidate the mechanisms that explain the hypothesized ethnic disparity in Alzheimer's disease and Alzheimer-related dementias by evaluating the roles of vascular disease risk factors, educational attainment and socio-economic status among others. This research will also delve deeply into the differences in informal caregiving for Mexican American and non Hispanic whites with cognitive impairment and dementia. Caregiver burden and mental and physical health of caregivers will be examined toward efforts to develop interventions that build resilience in caregivers. A novel ability of this population-based study is to examine community resources for both patients and caregivers, and how these provisions differ by ethnicity. Using a rigorous mixed methods approach the study will identify the gap between available resources and needs for those with cognitive impairment and dementia. In this way we will be well positioned to propose ethnic-specific testable interventions that promote mental and physical health for those with cognitive impairment and dementia, as well as for those family members who provide the care. This research will therefore lead to improved well-being, autonomy and outcomes among those with cognitive impairment and dementia and their caregivers. The investigative team members have conducted research in this community for 20 years and are experts in Mexican American culture and health, cognitive impairment and dementia, epidemiologic methods, community needs assessment and health behavior research. As the Mexican American population continues its tremendous growth and aging it is vitally important to better understand the prevalence and outcomes of cognitive impairment and dementia in this population, and to rapidly develop interventions that address the burden of these common conditions in Mexican American adults, families, and communities.

Study Timeline

• Study First Submitted: 2018-01-11
• Study First Submitted QC: 2018-01-11
• Study First Posted: 2018-01-18
• Study Start: 2018-04-11
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-26
• Last Update Posted: 2024-02-28
• Primary Completion: 2025-03-30
• Study Completion: 2025-03-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 634

Inclusion Criteria

1. >64 years of age
2. MoCA < 26
3. Nueces County resident at least 6 months a year
4. English or Spanish speaking
5. Community dwelling or nursing home

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Exclusion Criteria

none

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Subjects with cognitive impairment	No interventions	Subjects with MoCA \<26
Caregivers	No interventions	Primary caregivers of subjects

Primary Outcome Measures

Name	Time	Method
Trajectory of cognitive function in Mexican Americans and non Hispanic whites	2 year follow-up after baseline	Change in cognitive function among subjects entered at baseline
Caregiver outcomes and changes over time	4 years	Comparative caregiver outcomes among Mexican Americans and non Hispanic whites
Prevalence of mild cognitive impairment and dementia in Mexican Americans and non Hispanic whites	2 year data collection	Prevalence estimates

Secondary Outcome Measures

Name	Time	Method
Needs and community available resources for cognitive impairment	2 years	An asset map and determination of needs

Trial Locations

Locations (1)

Corpus Christi Nueces County Health District; 🇺🇸 Corpus Christi, Texas, United States