NCT02052232已完成不适用
Study of Acute Muscle Protein Metabolism in Healthy Older Subjects
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Protein Metabolism
研究概览
简要总结
This is a randomized, double-blinded, crossover study to evaluate muscle protein metabolism during fasting and feeding in healthy older subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 60 and ≤ 75 years
- •Body Mass Index (BMI) > 23.0 to < 30.0
- •Ability (with or without the aid of an assistive device) to climb a flight of 10 stairs or walk an equivalent of 1 city block without assistance
- •Currently not participating in a formal exercise or training program and agrees to refrain from intense physical activity from screening through the completion of the study.
排除标准
- •Diagnosis of diabetes
- •Active pursuit of weight loss
- •Poorly controlled hypertension or hypotension
- •Untreated hypothyroidism or hyperthyroidism
- •Anemia or abnormally functioning kidneys or liver
- •A significant cardiovascular event within ≤ 6 months; or stated history of congestive heart failure; or evidence of clinically active cardiovascular disease assessed during the screening EKG
- •Peripheral arterial disease or other diseases that preclude proper limb blood flow
- •Chronic, contagious, infectious disease
- •Current infection or corticosteroid treatment within the last 3 months
- •Clotting or bleeding disorders, stated history of Deep Vein Thrombosis (DVT) and/or a known hypercoagulable condition
- •In condition deemed unsuitable for study based upon study physician assessment
- •Surgery requiring >2 days of hospitalization in the last 3 weeks and/or planned elective surgery requiring >2 days of hospitalization during the course of the study
- •Current active malignant disease or was treated within the last 6 months for cancer
- •An amputee
- •Obstruction of the gastrointestinal tract, inflammatory bowel disease, short bowel syndrome or other forms of gastrointestinal disease
- •Diagnosed with, or has a history of severe dementia or delirium, eating disorder, history of significant neurological or psychiatric disorder, alcoholism, substance abuse
- •Cannot refrain from taking
- •High doses of fish oil, or omega-3 supplements, or high doses of vitamin D
- •Medications/dietary supplements/herbals or substances that are considered anabolic, or reduce weight
- •Any pulmonary anti-inflammatory medication or bronchodilators on the day of and 48 hours prior to study visits 1 and 2
- •NSAIDS or acetaminophen on the day of and 48 hours prior to study visits 1 and 2
- •Chronic use of nicotine
- •Allergic or intolerant to any ingredient found in the study products
研究组 & 干预措施
Control
Active Comparator
Control protein powder sachet
干预措施: Control protein powder sachet (Other)
Experimental
Experimental
Experimental protein powder sachet
干预措施: Experimental protein powder sachet (Other)
结局指标
主要结局
Protein Metabolism
时间窗: Change from - 1 to + 5 hours
Study Visit 1 and Study Visit 2
次要结局
- Microvascular Blood Flow(Change from -1 to +5 hours)
- Macrovascular Blood Flow(Change from -1 to +5 hours)
- Glycemic Markers(Change from -1 to +5 hours)
研究者
研究点 (1)
Loading locations...
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