The Use of Thromboelastography in Burn Injury to Improve Burn Coagulopathy Evaluation and Intervention
概览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- Francesco Egro
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Thromboelastography
概览
简要总结
This pilot study examines the use of thromboelastography (TEG), a specialized blood test, to evaluate clotting abnormalities in burn patients. The study aims to understand how burn injuries impact the body's ability to form and break down blood clots over time. Specifically, the investigators will research whether the percentage of total body surface area burned (%TBSA) is associated with changes in blood clotting, track the evolution of clotting patterns during the first four weeks following a burn injury, and explore whether these changes can predict recovery or complications. By providing new insights into clotting dynamics in burn patients, the study seeks to improve diagnostic methods, enhance monitoring strategies, and guide treatments to optimize patient care and outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients admitted with acute burn injuries
- •Aged 18 years and older
- •Provided consent to participate in the study
排除标准
- •Patients with a history of venous thromboembolism or hyper/hypocoagulopathy
结局指标
主要结局
Thromboelastography
时间窗: Duration of hospital length of stay, up to 28 days
Thromboelastography (TEG) evaluates blood's clotting ability by measuring the strength and elasticity of a clot over time, producing a dynamic graph. The following outcome measures will be assessed at specific time points (Day 1, Day 7, Day 14, Day 21, and Day 28): 1. Reaction Time (R) (seconds) - The time from test initiation until the first detectable clot formation. 2. Kinetic Time (K) (seconds) - The time from initial clot formation to a defined clot strength threshold. 3. Maximum Amplitude (MA) (millimeters) - The peak strength of the formed clot. 4. Alpha Angle (degrees) - The slope of the clot formation curve, representing the rate of clot development. 5. Lysis at 30 Minutes (Ly30) (percentage of MA) - The percentage of clot degradation occurring 30 minutes after reaching maximum amplitude. Each parameter will be measured at the specified time points, and values will be aggregated into one TEG graph.
次要结局
- Hospital Length of Stay(Duration of hospital length of stay, up to 28 days)
- Complications During Treatment(Duration of hospital length of stay, up to 28 days)
研究者
Francesco Egro
Associate Professor
University of Pittsburgh