Interstitial Lung Disease Misdiagnosis in Cardiac Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 80
- 主要终点
- Accuracy of initial HRCT interpretation
研究概览
简要总结
Aim of the study To determine the frequency misdiagnosis of cardiac congestion as interstitial lung disease based on initial High Resolution CT interpretation alone.
To identify specific HRCT findings that are more commonly associated with misdiagnosis versus correct diagnosis of the underlying condition.
To establish diagnostic criteria or HRCT patterns that distinguish cardiac congestion from interstitial lung disease
详细描述
Observational study of 150 patients found that cardiac congestion was misdiagnosed as interstitial lung disease in 24% of cases on initial HRCT imaging alone. Echocardiography and clinical correlation were needed to make the correct diagnosis .
Misdiagnosis can lead to inappropriate treatment with immunosuppressive drugs which could exacerbate right heart failure in patients who actually have cardiac congestion. Correct diagnosis is important for prognosis and management.
Subtle findings like upper lobe predominance of opacities, septal lines and a mosaic attenuation pattern on HRCT favor interstitial lung disease, while diffuse ground glass with central and perihilar distribution favors cardiac congestion .
Associated findings on HRCT like enlarged cardiac silhouette, pleural and pericardial effusions help suggest the diagnosis of cardiac congestion over idiopathic interstitial pneumonia .
Integrating clinical data on risk factors for heart failure, echocardiography findings and follow-up imaging response to diuretic therapy can help differentiate the two conditions when HRCT is non-specific
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent HRCT imaging of the chest for evaluation of suspected interstitial lung disease
- •Initial radiology report included a definitive diagnosis of interstitial lung disease patterns
- •Age 18+ years
- •No prior history of pulmonary or cardiac
排除标准
- •Inconclusive or unclear initial HRCT report
- •Underlying diagnosis other than interstitial lung disease or cardiac congestion
结局指标
主要结局
Accuracy of initial HRCT interpretation
时间窗: baseline
(percentage of cases initially read as interstitial lung disease that were later found to be cardiac congestion)
次要结局
- Time to correct diagnosis(baseline)
研究者
Hend Mohamed Sayed Mohamed
doctor
Assiut University