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临床试验/NCT05981612
NCT05981612招募中不适用

Effects of Emotional Reactivity on Decision-Making in Adolescents With Nonsuicidal Self-Injury

University of Electronic Science and Technology of China1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2023年12月6日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
80
试验地点
1
主要终点
The prediction of PEs of punishment decisions

研究概览

简要总结

Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the actual received rewards as well as the associated emotional reactions. These processes have recently been computationally formalized as prediction errors (PE), specifically reward PEs, valence PEs, and arousal PEs (Heffner et al., 2021; Nat Hum Behav). In the current study, the investigators aim to investigate whether these PEs make discernible contributions to social decisions in the context of unfair experiences among adolescents with NSSI and matched healthy control adolescents (HC). Specifically the investigators hypothesized that: 1) reward and emotional PEs show significant predictions of punishment decisions in both groups, 2) however, compared to HC adolescents, the NSSI group will exhibit selective dysfunctions in emotional but not reward PEs leading to punish a norm proposer who provided unfair offers.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
15 Years 至 18 Years(Child, Adult)
性别
All
接受健康志愿者

入选标准

  • 15-18 years
  • right-handed
  • normal or corrected normal visual acuity
  • meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)

排除标准

  • diagnosis of borderline personality disorder, major depressive disorder, other
  • psychiatric disorders, etc.
  • high suicidal risk
  • recent use of medications that can affect neural activity
  • have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months
  • have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)

结局指标

主要结局

The prediction of PEs of punishment decisions

时间窗: About 20 minutes

All PEs and groups (NSSI, HC) will be used in a regression model to examined whether there is any alteration in the NSSI group when PEs are predicted to punishment (reject) decisions.

Reward prediction errors (PEs)

时间窗: About 20 minutes

Reward PEs will be calculated by the differences between the experienced (when be offered) reward and predicted (before the offer) reward.

Valence prediction errors (PEs)

时间窗: About 20 minutes

Valence PEs will be calculated by the differences between the experienced emotional valence and predicted emotional valence.

Arousal prediction errors (PEs)

时间窗: About 20 minutes

Arousal PEs will be calculated by the differences between the experienced emotional arousal and predicted emotional arousal.

次要结局

未报告次要终点

研究者

发起方
University of Electronic Science and Technology of China
申办方类型
Other
责任方
Principal Investigator
主要研究者

Benjamin Becker

Professor

University of Electronic Science and Technology of China

研究点 (1)

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