Progressive Strength Training in Spinal Muscular Atrophy

Not Applicable

Completed

• Conditions: Muscular Atrophy, Spinal

• Registration Number: NCT01233817
• Lead Sponsor: University of Utah

Brief Summary

The proposed feasibility study is necessary to test if children and young adults will participate in and adhere to a 12-week, home-based, supervised progressive strength training exercise program and to obtain preliminary data that will subsequently allow us to determine the safety and impact of strength training in spinal muscular atrophy. Our pilot study will address 3 aims: (1) Ascertain the feasibility of, and potential barriers to, participation in and adherence to a 12-week home-based, supervised, progressive strength training exercise program in children and young adults aged 5-21 years with SMA types II and III; (2) Determine the safety and tolerability of progressive strength training in a pilot study sample of children and young adults with SMA types II and III; and (3) Determine candidate outcome measures.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-06
• Study First Submitted: 2010-10-19
• Study First Submitted QC: 2010-11-01
• Study First Posted: 2010-11-03
• Results First Submitted: 2012-12-05
• Results First Submitted QC: 2013-02-05
• Results First Posted: 2013-03-12
• Primary Completion: 2013-06
• Study Completion: 2013-06
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-15
• Last Update Posted: 2017-06-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• age 5-21 years
• diagnosis of SMA type II or III
• at least antigravity strength in elbow flexors
• ability to follow commands and stay on task
• place of residence within a 60-minute or 60-mile drive of the University of Utah

Exclusion Criteria

• planned surgery or out-of-town trips during the proposed intervention period
• inability to travel to study center for testing
• neurological diagnosis other than SMA

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Strength	12 weeks	Primary Outcome Measure was muscle strength. Strength was measured using a fixed myometry evaluation, quantitative muscle analysis (QMA). QMA utilizes a relative fixed point for the participant to exert effort. Each muscle of interest was tested using QMA.

Trial Locations

Locations (1)

University of Utah; 🇺🇸 Salt Lake City, Utah, United States