The Effect of Blood Flow Rate on Dialysis Recovery Time in Patients Undergoing Maintenance Hemodialysis
- Conditions
- ESRDHemodialysis-Induced SymptomFatigue
- Interventions
- Other: ControlOther: Blood Flow Rate Reduction
- Registration Number
- NCT03943212
- Lead Sponsor
- Satellite Healthcare
- Brief Summary
A majority of patients with end-stage renal disease (ESRD) on in-center hemodialysis (HD) require several hours to recover from fatigue after an HD session. Evidence for practical interventions to improve this recovery time from conventional in-center HD is lacking. This study investigates the effects of reducing HD blood flow rates on patients' self-reported post-dialysis fatigue.
- Detailed Description
Post-dialysis fatigue reduces patients' quality of life and is also associated with cardiovascular events and mortality. Dialysis recovery time (DRT) is a measure of post-dialysis fatigue. Internationally, it has been found that more than a quarter of maintenance HD patients report \>6 hours of DRT. The interventions showing the most improvement in DRT involve increases in treatment time, suggesting that post-dialysis fatigue may be in part related to the rate of solute clearance. Solute clearance rate is just one part of extending dialysis time, and its effect on DRT in patients undergoing typical-length dialysis sessions is not known. There is scant evidence to guide blood flow rate prescriptions aside from meeting clearance targets. Blood flow rate reductions are easily-implementable interventions that would slow solute clearance rates and may have an effect on post-dialysis fatigue.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 102
- A diagnosis of end-stage renal disease undergoing hemodialysis in the San Francisco Bay Area at approved Satellite Healthcare dialysis centers.
- Dialysis recovery time of 6 or more hours.
- Not hospitalized in the 7 days prior to study
- Currently or possibly pregnant, currently trying to become pregnant
- Inability to provide informed consent
- Inability to provide responses to survey questions
- Planned move away from the current hemodialysis center within the study period
- Undergoing nocturnal hemodialysis, planned changed to nocturnal or peritoneal dialysis, planned kidney transplant within the study period, or other major planned change in hemodialysis prescription
- Primary nephrologist objection to enrollment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control Control Participants will continue to receive regularly-scheduled hemodialysis without any changes to the prescription. Blood Flow Rate Reduction Blood Flow Rate Reduction Participants will have their hemodialysis blood flow rate reduced on their regular schedule.
- Primary Outcome Measures
Name Time Method Dialysis Recovery Time 4 weeks Mean difference in change in Dialysis Recovery Time between the Blood Flow Rate Reduction group and the Control group. Dialysis recovery time is measured by asking the question, "How long did it take you to recover from dialysis?"
- Secondary Outcome Measures
Name Time Method London Evaluation of Illness 4 weeks Mean difference in change in survey responses for measures of quality of life as assessed by the London Evaluation of Illness Tool.
Trial Locations
- Locations (18)
Satellite Dialysis Mountain View
🇺🇸Mountain View, California, United States
Satellite Dialysis Gilroy
🇺🇸Gilroy, California, United States
Satellite Dialysis Silver Creek
🇺🇸San Jose, California, United States
Satellite Dialysis Capitola
🇺🇸Capitola, California, United States
Satellite Dialysis Watsonville
🇺🇸Watsonville, California, United States
Satellite Dialysis Milpitas
🇺🇸Milpitas, California, United States
Satellite Dialysis San Mateo
🇺🇸San Mateo, California, United States
Satellite Dialysis Sunnyvale
🇺🇸Sunnyvale, California, United States
Satellite Dialysis Santa Teresa
🇺🇸San Jose, California, United States
Satellite Dialysis Daly City
🇺🇸Daly City, California, United States
Satellite Dialysis West San Leandro
🇺🇸San Leandro, California, United States
Satellite Dialysis Menlo Park
🇺🇸Menlo Park, California, United States
Satellite Dialysis Stevens Creek
🇺🇸San Jose, California, United States
Satellite Dialysis East San Jose
🇺🇸San Jose, California, United States
Satellite Dialysis White Road
🇺🇸San Jose, California, United States
Satellite Dialysis South San Jose
🇺🇸San Jose, California, United States
Satellite Dialysis Bascom
🇺🇸San Jose, California, United States
Satellite Dialysis South San Francisco
🇺🇸South San Francisco, California, United States