To know the efficacy of topical carboxymethylcellulose (0.5%), cyclosporine (0.03%) & chloroquine (0.03% ) in cases of dry eye disease
Phase 2
- Conditions
- Health Condition 1: H048- Other disorders of lacrimal system
- Registration Number
- CTRI/2023/07/054823
- Lead Sponsor
- IMS BH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Cases of moderate to severe dry eye disease with best corrected visual acuity of more than or equal to 660 attending the outpatient department of RIO, IMS, BHU.
Cases giving written consent to participate in the study
Exclusion Criteria
sensitivity to eyedrops
ocular infection, ocular injury or trauma or past ocular surgery.
uncontrolled systemic disease
contact lens wearer.
chronic alcoholics, pregnant or lactating women. already received treatment for dry eye disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method •Slit lamp biomicroscopy <br/ ><br>•Schirmer’s test using 41 no Whatmann filter paper strips <br/ ><br>•Tear film break up time using fluorescein staininG <br/ ><br>•Ocular Surface disease index (OSDI) <br/ ><br>•Fluorescein stain score <br/ ><br>Timepoint: <br/ ><br>DAY 0 <br/ ><br>WEEK 1 <br/ ><br>WEEK 4 <br/ ><br>WEEK 8 <br/ ><br>WEEK 12 <br/ ><br>
- Secondary Outcome Measures
Name Time Method VISUAL ACUITY <br/ ><br>BEST CORRECTED VISUAL ACUITY <br/ ><br>SLIT LAMP BIOMICROSCOPYTimepoint: DAY 0 <br/ ><br>WEEK 1 <br/ ><br>WEEK 4 <br/ ><br>WEEK 8 <br/ ><br>WEEK 12