Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis
- Conditions
- Pediatric Multiple Sclerosis
- Registration Number
- NCT01396343
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
The purpose of this study is to better understand multiple sclerosis (MS) in children and adolescents, to learn if it differs from adult MS and to investigate if genes or environmental exposures or a combination of both put children and adolescents at risk for getting MS.
- Detailed Description
The overall goal of this project is to determine whether well-established environmental and genetic risk factors for adult onset MS play an important role in susceptibility to pediatric-onset MS. Our study design is based on the hypothesis that genetic influences, specifically variation at HLA-DRB1 and other confirmed non-MHC MS loci, as well as environmental exposures including EBV infection and tobacco smoke, contribute to disease risk. In addition, we will also examine the relationship between serum levels of 25(OH) vitamin D3 and prior vitamin D status, and risk for pediatric onset MS. Finally, we will investigate whether specific G x E, and other multivariable relationships influencing risk exist for pediatric-onset MS. There are 16 collaborating sites other than UCSF that will enroll cases and controls for this study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1276
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identify risk factors and their respective contribution to developing pediatric multiple sclerosis 4 year data collection, 1 year analysis The primary objective of this study is to determine if risk factors identified for adult MS such as HLA-DRB1\*1501/1503, EBV, 25(OH) vitamin D3 insufficiency, and exposure to cigarette smoking are also risk factors for pediatric MS, and if there are interactions between them analyzing data collected from questionnaires for environmental exposure, demographic and food frequency as well as sample blood specimens.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (17)
The Blue Bird Circle Clinic for MS at Texas Children's Hospital
🇺🇸Houston, Texas, United States
Pediatric Neurology Clinic, Primary Children's Hospital
🇺🇸Salt Lake City, Utah, United States
Pediatric MS Clinic, Ann & Robert H. Lurie Children's Hospital of Chicago
🇺🇸Chicago, Illinois, United States
Pediatric MS Clinic, Children's Hospital Boston
🇺🇸Boston, Massachusetts, United States
Pediatric MS Center, University of Texas, Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Pediatric MS Clinic, Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
New York University Langone Medical Center
🇺🇸New York, New York, United States
The Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
UCSF Pediatric MS Center
🇺🇸San Francisco, California, United States
Children's Hospital Colorado, University of Colorado School of Medicine
🇺🇸Aurora, Colorado, United States
Pediatric MS Clinic, Children's Hospital of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Pediatric MS Clinic, Children's Hospital, Loma Linda University
🇺🇸San Bernardino, California, United States
Regional Pediatric MS Center at Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Pediatric MS Center of the Jacobs Neurological Institute, University of Buffalo
🇺🇸Buffalo, New York, United States
Partners Pediatric MS Center at the Massachusetts General Hospital for Children
🇺🇸Boston, Massachusetts, United States
Center for pediatric-onset demyelinating diseases at the Children's Hospital of Alabama, Birmingham
🇺🇸Birmingham, Alabama, United States
Pediatric MS Clinic, Children's National Medical Center
🇺🇸Washington, District of Columbia, United States