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Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis

Completed
Conditions
Pediatric Multiple Sclerosis
Registration Number
NCT01396343
Lead Sponsor
University of California, San Francisco
Brief Summary

The purpose of this study is to better understand multiple sclerosis (MS) in children and adolescents, to learn if it differs from adult MS and to investigate if genes or environmental exposures or a combination of both put children and adolescents at risk for getting MS.

Detailed Description

The overall goal of this project is to determine whether well-established environmental and genetic risk factors for adult onset MS play an important role in susceptibility to pediatric-onset MS. Our study design is based on the hypothesis that genetic influences, specifically variation at HLA-DRB1 and other confirmed non-MHC MS loci, as well as environmental exposures including EBV infection and tobacco smoke, contribute to disease risk. In addition, we will also examine the relationship between serum levels of 25(OH) vitamin D3 and prior vitamin D status, and risk for pediatric onset MS. Finally, we will investigate whether specific G x E, and other multivariable relationships influencing risk exist for pediatric-onset MS. There are 16 collaborating sites other than UCSF that will enroll cases and controls for this study.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
1276
Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Identify risk factors and their respective contribution to developing pediatric multiple sclerosis4 year data collection, 1 year analysis

The primary objective of this study is to determine if risk factors identified for adult MS such as HLA-DRB1\*1501/1503, EBV, 25(OH) vitamin D3 insufficiency, and exposure to cigarette smoking are also risk factors for pediatric MS, and if there are interactions between them analyzing data collected from questionnaires for environmental exposure, demographic and food frequency as well as sample blood specimens.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (17)

The Blue Bird Circle Clinic for MS at Texas Children's Hospital

🇺🇸

Houston, Texas, United States

Pediatric Neurology Clinic, Primary Children's Hospital

🇺🇸

Salt Lake City, Utah, United States

Pediatric MS Clinic, Ann & Robert H. Lurie Children's Hospital of Chicago

🇺🇸

Chicago, Illinois, United States

Pediatric MS Clinic, Children's Hospital Boston

🇺🇸

Boston, Massachusetts, United States

Pediatric MS Center, University of Texas, Southwestern Medical Center

🇺🇸

Dallas, Texas, United States

Pediatric MS Clinic, Washington University School of Medicine

🇺🇸

Saint Louis, Missouri, United States

New York University Langone Medical Center

🇺🇸

New York, New York, United States

The Cleveland Clinic

🇺🇸

Cleveland, Ohio, United States

UCSF Pediatric MS Center

🇺🇸

San Francisco, California, United States

Children's Hospital Colorado, University of Colorado School of Medicine

🇺🇸

Aurora, Colorado, United States

Pediatric MS Clinic, Children's Hospital of Philadelphia

🇺🇸

Philadelphia, Pennsylvania, United States

Pediatric MS Clinic, Children's Hospital, Loma Linda University

🇺🇸

San Bernardino, California, United States

Regional Pediatric MS Center at Mayo Clinic

🇺🇸

Rochester, Minnesota, United States

Pediatric MS Center of the Jacobs Neurological Institute, University of Buffalo

🇺🇸

Buffalo, New York, United States

Partners Pediatric MS Center at the Massachusetts General Hospital for Children

🇺🇸

Boston, Massachusetts, United States

Center for pediatric-onset demyelinating diseases at the Children's Hospital of Alabama, Birmingham

🇺🇸

Birmingham, Alabama, United States

Pediatric MS Clinic, Children's National Medical Center

🇺🇸

Washington, District of Columbia, United States

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