Application of Intrahepatic Arterial Infusion Chemotherapy for Patients With High Risk of Liver Metastases After Pancreatic Cancer Surgery

Not Applicable

• Conditions: Liver Metastases; Who Have High CTCs Count in Portal Venous Blood; Pancreatic Ductal Adenocarcinoma
• Interventions: Device: Intrahepatic Arterial Infusion

• Registration Number: NCT03687853
• Lead Sponsor: Peking University Third Hospital

Brief Summary

Clinical results on intra-arterial adjuvant chemotherapy for prevention

of liver metastasis following curative resection of pancreatic cancer

Detailed Description

In this study, the investigator try to select 80 patients who received radical surgery for pancreatic cancer, whose circulating tumor cells(CTCs) count then performed on intraoperative portal venous blood to predict postoperative liver metastasis and were divided into two groups. for those who have high CTCs count may have more chance for the occurrence of postoperative liver metastasis was applied hepatic arterial perfusion chemotherapy with minimal dynamic randomization. The aim is to evaluate the feasibility of hepatic arterial infusion chemotherapy for the prevention of postoperative liver metastasis and improvement of prognosis of pancreatic cancer, so as to further improve postoperative management of pancreatic cancer

Study Timeline

• Study Start: 2017-01-01
• Study First Submitted: 2018-08-20
• Status Verified: 2018-09
• Study First Submitted QC: 2018-09-26
• Last Update Submitted: 2018-09-26
• Study First Posted: 2018-09-27
• Last Update Posted: 2018-09-27
• Primary Completion: 2018-12-31
• Study Completion: 2019-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• pancreatic cancer patients who received the radical operation

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Exclusion Criteria

• who accepted chemotherapy before operation or who cannot or do not will to accepted enrolled into this study

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intrahepatic Arterial Infusion chemotherapy	Intrahepatic Arterial Infusion	chemotherapy through intrahepatic arterial Infusion is one of the most widely used liver tumor treatments.

Primary Outcome Measures

Name	Time	Method
Death	up to 12 months	Overall survival time after operation

Trial Locations

Locations (1)

Department of General Surgery,Peking University Third Hospital; 🇨🇳 Beijing, Beijing, China