NCT00812396已完成1 期
A Randomized, Single-Blind, Placebo-Controlled, Fixed-Sequence, Single-Dose, Parallel Design Study to Utilize Comparative Proteomics to Identify Early Biomarkers of Muscle Anabolism
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 30
- 主要终点
- comparative proteomics on proteins present in the vastus lateralis or plasma
研究概览
简要总结
This study will evaluate the ability of comparative proteomics to identify early biomarkers of muscle anabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •subject is a healthy male between 18 and 40 years old
- •subject's weight is stable over the past 3 months
- •subject agrees to refrain from consuming alcohol during study
- •subject agrees to consume no caffeine while in the CRU
- •subject agrees to follow meat-free diet
- •subject is willing to avoid strenuous activity
- •subject has been a nonsmoker for at least 6 months
排除标准
- •subject is a regular user of illicit drugs
- •subject has taken androgenic steroids in the past 12 months
- •subject has participated in sports events, resistance training, or moderate to heavy endurance training in the past month
- •subject has prostate cancer
- •subject has HIV and/or hepatitis B or C
研究组 & 干预措施
1
Active Comparator
Low dose testosterone
干预措施: Comparator: low dose testosterone (Drug)
2
Active Comparator
High dose testosterone
干预措施: Comparator: high dose testosterone (Drug)
3
Placebo Comparator
Placebo
干预措施: Comparator: placebo (Drug)
结局指标
主要结局
comparative proteomics on proteins present in the vastus lateralis or plasma
时间窗: 1 week
次要结局
- mRNA or miRNA expression in the vastus lateralis or in peripheral blood(1 week)
研究者
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