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Clinical Trials/NCT04700553
NCT04700553
Not yet recruiting
Not Applicable

Efficacy of Localized Muscle Vibration on Lower Extremity Functional Ability in Patients With Stroke: A Randomized Controlled Trial

Giuseppe Annino1 site in 1 country35 target enrollmentJuly 1, 2023
ConditionsStroke

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Stroke
Sponsor
Giuseppe Annino
Enrollment
35
Locations
1
Primary Endpoint
Barthel Index (BI)
Status
Not yet recruiting
Last Updated
2 years ago

Overview

Brief Summary

Background and objectives: Lower extremity functional impairments are common consequences of stroke. Thus, continuous examination of effective treatment interventions for lower extremity functions after stroke is a necessity. Localized muscle vibration (LMV) is one of the treatment interventions that incorporate sensory stimulation to improve motor cortical excitability. This study aimed to investigate the influences of 10-minutes lower extremity LMV application along with conventional physical therapy (CPT) on activities of daily living (ADL) and motor recovery on the hemiparetic lower extremity post-stroke.

Methods: A sample of 37 patients with stroke (8 females) was randomly allocated to either conventional physical therapy (CPT) control group (n=18) or conventional physical therapy and localized muscle vibration (CPT+LMV) experimental group (n=19). All patients received 3 sessions per week of CPT for 8 weeks. The CPT+LMV experimental group received 10-minute LMV at the end of each CPT session. The outcome measures used were the Barthel Index (BI), Berg Balance Scale (BBS), and goniometry for Range of Motion (ROM) assessment.

Detailed Description

All patients in both experimental and control groups received CPT protocol consisted of 30 minutes of manual resistance exercise (3 sets/10 repetitions each for knee extensors and flexors) and 30 minutes of treadmill training, short breaks (1-5 minutes) were allowed, depending on the patient tolerance. The training was conducted for 3 days per week for 8 weeks. The patients in CPT+LMV experimental group received localized muscle vibration at the end of each CPT session. The LMV was applied for 10 minutes perpendicularly along quadriceps muscle fibers. The frequency set at 30 Hz, amplitude of 2 mm.

Registry
clinicaltrials.gov
Start Date
July 1, 2023
End Date
August 31, 2023
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Giuseppe Annino
Responsible Party
Sponsor Investigator
Principal Investigator

Giuseppe Annino

Professor

University of Rome Tor Vergata

Eligibility Criteria

Inclusion Criteria

  • Confirmed diagnosis of stroke

Exclusion Criteria

  • If they had any serious orthopedic injury/disease, cardiopulmonary problems or suffered from a neurological disease (other than stroke).

Outcomes

Primary Outcomes

Barthel Index (BI)

Time Frame: Change from baseline activity of daily livings at 8 weeks

The Barthel Index of Activities of Daily Living (BI). Measure of functional disability. The BI consisting of 10 common activities of daily living (ADL) activities, administered through direct observation. These are assessed for independence/ dependence and scored via an arbitrary weighting system (originally applied to reflect nursing care and social acceptability). Eight of the ten items represent activities related to personal care; the remaining 2 are related to mobility. The index yields a total score out of 100 - the higher the score, the greater the degree of functional independence

Secondary Outcomes

  • Berg Balance Scale(Change from baseline balance at 8 weeks)
  • Manual Muscle Testing(Change from baseline range of motion at 8 weeks)
  • Modified Ashworth Scale(Change from baseline range of motion at 8 weeks)
  • Goniometry(Change from baseline range of motion at 8 weeks)

Study Sites (1)

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