Effects of Intranasal Oxytocin on Emotion Regulation
Overview
- Phase
- Early Phase 1
- Intervention
- Oxytocin
- Conditions
- Healthy
- Sponsor
- University of Electronic Science and Technology of China
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Oxytocin effects on neural activity during emotion regulation task
- Last Updated
- 7 years ago
Overview
Brief Summary
The aim is to examine whether intranasal oxytocin will influence the individuals' emotion regulation ability and related neural mechanisms.
Detailed Description
In the present study, the investigators plan to conduct a between-subject, double-blind, placebo-controlled experiment to investigate the effects of oxytocin on neural, physiological and behavior activity related to emotion regulation. The emotion regulation ability will be assessed by emotional go-nogo task and cognitive reappraisal task. The neural activity will be explored by functional magnetic resonance imaging (fMRI). And the investigators will record participants' heart rate during fMRI to investigate the effects of oxytocin on heart rate variability in emotion regulation process. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety before self-administration, including Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS), Autism Spectrum Quotient (ASQ), Empathy Quotient (EQ), Interpersonal Reactivity Index (IRI), Action Control Scale (ACS), Emotion Regulation Questionnaire (ERQ), Berkley Expressivity Questionnaire (BEQ), and so on.
Investigators
Benjamin Becker
Professor / Research group leader
University of Electronic Science and Technology of China
Eligibility Criteria
Inclusion Criteria
- •healthy subjects without past or current psychiatric or neurological disorders
Exclusion Criteria
- •history of head injury;
- •claustrophobia;
- •medical or psychiatric illness.
Arms & Interventions
Oxytocin
intranasal administration of oxytocin
Intervention: Oxytocin
Placebo
intranasal administration of placebo
Intervention: Placebo
Outcomes
Primary Outcomes
Oxytocin effects on neural activity during emotion regulation task
Time Frame: Between 45-110 minutes after the intranasal administration of oxytocin
Neural activity will be measured by functional magnetic resonance imaging (fMRI). Differences in activity of prefrontal cortex (PFC) and amygdala will be compared between oxytocin and placebo groups during emotional go-nogo task and cognitive reappraisal task.
Secondary Outcomes
- Oxytocin effects on behavior response during emotion regulation task(Between 45-110 minutes after the intranasal administration of oxytocin)
- Oxytocin effects on neural activity during resting-state(Between 35-45 minutes after the intranasal administration of oxytocin)
- Oxytocin effects on heart rate variability during emotion regulation task(Between 45-110 minutes after the intranasal administration of oxytocin)
- Oxytocin effects on heart rate variability during resting-state(Between 35-45 minutes after the intranasal administration of oxytocin)