Effects of Intranasal Oxytocin on Emotion Regulation
试验速览
- 阶段
- 早期 1 期
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Oxytocin effects on neural activity during emotion regulation task
研究概览
简要总结
The aim is to examine whether intranasal oxytocin will influence the individuals' emotion regulation ability and related neural mechanisms.
详细描述
In the present study, the investigators plan to conduct a between-subject, double-blind, placebo-controlled experiment to investigate the effects of oxytocin on neural, physiological and behavior activity related to emotion regulation. The emotion regulation ability will be assessed by emotional go-nogo task and cognitive reappraisal task. The neural activity will be explored by functional magnetic resonance imaging (fMRI). And the investigators will record participants' heart rate during fMRI to investigate the effects of oxytocin on heart rate variability in emotion regulation process.
All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety before self-administration, including Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS), Autism Spectrum Quotient (ASQ), Empathy Quotient (EQ), Interpersonal Reactivity Index (IRI), Action Control Scale (ACS), Emotion Regulation Questionnaire (ERQ), Berkley Expressivity Questionnaire (BEQ), and so on.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy subjects without past or current psychiatric or neurological disorders
排除标准
- •history of head injury;
- •claustrophobia;
- •medical or psychiatric illness.
研究组 & 干预措施
Oxytocin
intranasal administration of oxytocin
干预措施: Oxytocin (Drug)
Placebo
intranasal administration of placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Oxytocin effects on neural activity during emotion regulation task
时间窗: Between 45-110 minutes after the intranasal administration of oxytocin
Neural activity will be measured by functional magnetic resonance imaging (fMRI). Differences in activity of prefrontal cortex (PFC) and amygdala will be compared between oxytocin and placebo groups during emotional go-nogo task and cognitive reappraisal task.
次要结局
- Oxytocin effects on behavior response during emotion regulation task(Between 45-110 minutes after the intranasal administration of oxytocin)
- Oxytocin effects on neural activity during resting-state(Between 35-45 minutes after the intranasal administration of oxytocin)
- Oxytocin effects on heart rate variability during emotion regulation task(Between 45-110 minutes after the intranasal administration of oxytocin)
- Oxytocin effects on heart rate variability during resting-state(Between 35-45 minutes after the intranasal administration of oxytocin)
研究者
Benjamin Becker
Professor / Research group leader
University of Electronic Science and Technology of China