Parathyroid Cancer Versus Atypical Parathyroid Neoplasm; Investigating Their Clinical Characteristics and Biological Behavior

Completed

• Conditions: Parathyroid Carcinoma; Parathyroid Neoplasm
• Interventions: Other: Chart Review

• Registration Number: NCT03046524
• Lead Sponsor: M.D. Anderson Cancer Center

Brief Summary

Objectives:

1. Identify the clinical characteristics of parathyroid (PTH) cancer and PTH atypical neoplasms

2. Investigate if PTH carcinoma and atypical neoplasm present a biological behaviour and have a different impact on the health of the patients

Detailed Description

Data between the years of 1/1/2002 and 12/31/2013 will be analyzed. The medical records of all adult patients that had a parathyroidectomy for primary PHPT in MD Anderson Cancer Center will be screened in order to identify patients that had a histopathological diagnosis of parathyroid carcinoma or atypical parathyroid neoplasm.

Study Timeline

• Study Start: 2015-10-06
• Study First Submitted: 2017-02-02
• Study First Submitted QC: 2017-02-06
• Study First Posted: 2017-02-08
• Primary Completion: 2017-10-16
• Study Completion: 2017-10-16
• Status Verified: 2018-02
• Last Update Submitted: 2018-02-06
• Last Update Posted: 2018-02-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• All patients from MDACC diagnosed with PHPT that have a histopathological diagnosis of PTH carcinoma or atypical parathyroid neoplasm between the years 1/1/2002 and 12/31/2013

Exclusion Criteria

• Pediatric patients
• Cases with incomplete records
• Patients where the follow-up will be less than six months

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Atypical Parathyroid Neoplasm	Chart Review	Charts from participants with parathyroid tumors with some atypical features found in parathyroid carcinoma, but not enough histologic criteria to make the diagnosis of parathyroid carcinoma.
Parathyroid Carcinoma	Chart Review	Charts from participants with histopathological diagnosis of parathyroid carcinoma.

Primary Outcome Measures

Name	Time	Method
Information Collected on Clinical Characteristics of Parathyroid (PTH) Cancer and PTH Atypical Neoplasms by Conducting a Retrospective Chart Review	5 years
Information Collected on PTH Carcinoma's Biological Behaviour and Impact on the Health of the Patients by Conducting a Retrospective Chart Review	5 years
Information Collected on Atypical Neoplasm's Biological Behaviour and Impact on the Health of the Patients \by Conducting a Retrospective Chart Review	5 years

Trial Locations

Locations (1)

University of Texas MD Anderson Cancer Center; 🇺🇸 Houston, Texas, United States