Immediate Pressor Response to Oral Salt

Not Applicable

Recruiting

• Conditions: High Blood Pressure
• Interventions: Other: salt

• Registration Number: NCT06226636
• Lead Sponsor: Mulungushi University

Brief Summary

The goal of this study is to establish a diagnostic accuracy of an immediate pressor response to oral salt (IPROS) to identify salt sensitivity of blood pressure (SSBP)

Detailed Description

Participants are given dietary salt and their BP is measured every 10 minutes for 2 hours. IPROS is diagnosed with significant mean arterial pressure increase

For SSBP, participants are put on high salt diet for a week and monitored and low salt week. The Mean arterial pressure difference between high salt and low salt is used to diagnose SSBP

Study Timeline

• Study Start: 2023-07-07
• Status Verified: 2024-01
• Study First Submitted: 2024-01-18
• Study First Submitted QC: 2024-01-18
• Last Update Submitted: 2024-01-18
• Study First Posted: 2024-01-26
• Last Update Posted: 2024-01-26
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Participants will be included if they are males or females, aged 18-65 years.

Exclusion Criteria

• Kidney disease, Cardiovascular disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
intervention	salt	intervention given

Primary Outcome Measures

Name	Time	Method
SSBP	2 weeks	Salt sensitivity status

Secondary Outcome Measures

Name	Time	Method
IPROS	2 hours	Immediate pressor response

Trial Locations

Locations (2)

Kanyama General Hospital; 🇿🇲 Lusaka, Zambia

Livingstone University Teaching Hospital; 🇿🇲 Livingstone, Southern, Zambia