Nutritional Status Among Older Adults. Risk Factors and Consequences of Malnutrition

Completed

• Conditions: Malnutrition

• Registration Number: NCT01161342
• Lead Sponsor: Uppsala University

Brief Summary

The aim of the study is to estimate the prevalence of malnutrition among older adults admitted to hospital and to analyse predictive factors for malnutrition. Further, the aim was to analyse the association between nutritional status and all-cause and cause-specific mortality.

The hypothesis is that malnourished patients have a higher mortality then well-nourished patients after three years.

Detailed Description

The baseline survey was a cross-sectional study of 1771 patients aged ≥65 years who were admitted to hospital. Nutritional status was assessed using the MNA instrument, and possible risk factors associated with malnutrition were recorded during the hospital stay. All-cause mortality was followed up after median 3.5 years s in a cohort study of 1767 participants. Cause-specific mortality was followed up after median 4.7 years in a cohort of 1767 participants. Previous dietary intake in middle-aged and older adults was recorded at basline in 725 participants, who had their nutritional status assessed with the MNA when admitted to hospital 10 years later.

Study Timeline

• Study Start: 2008-03
• Primary Completion: 2009-05
• Study Completion: 2009-05
• Study First Submitted: 2010-07-12
• Study First Submitted QC: 2010-07-12
• Study First Posted: 2010-07-13
• Status Verified: 2011-05
• Last Update Submitted: 2015-08-25
• Last Update Posted: 2015-08-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1771

Inclusion Criteria

• Patients 65 years or older

Exclusion Criteria

• unable to communicate and no relative could anwer the questions (n = 356)
• receiving palliative care (n = 44)
• impossible to measure height or weight (n = 22)
• miscellanious (n = 71)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All-cause mortality	All-cause mortality was analyzed after median 3.5 years.	Survival was calculated from the date of the MNA screening to the date of death.
Cause-specific mortality	Cause-specific mortality was analyzed after median 4.7 years.	Survival was calculated from the date of the MNA screening to the date of cause-specific death.
Nutritional status according to the screening instrument Mini Nutritional Assessment (MNA)	30 minutes	\[The 18 questions in the MNA instrument are weighted, and the threshold values of the instrument categorize patients into three nutritional status groups: well-nourished (MNA score 24-30), at risk of malnutrition (MNA score 17-23.5), or malnourished (MNA score \<17).