Comparison Between Intrathecal Injection of Hyperbaric Prilocaine Versus Hyperbaric Bupivacaine for Cystoscopic Procedures: A Prospective Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
研究概览
简要总结
This study aims to compare the intrathecal injection of hyperbaric prilocaine 2% versus hyperbaric bupivacaine 0.5% in cystoscopy procedures.
详细描述
Cystoscopy is a short surgical procedure in the field of urology that is very frequently performed. Spinal anesthesia (SA) is the choice because it has an easy implementation technique, fast onset, and low complications compared to general anesthesia.
One of the spinal anesthetic regimens often used is 0.5% hyperbaric bupivacaine, which has a two-segment regression time of around 65 minutes and requires 164 minutes for complete regression to the sacral dermatomes. However, bupivacaine, when used for relatively short procedures, causes various disadvantages including prolonged effects.
Prilocaine is an alternative to bupivacaine in short surgical procedures, including cystoscopy. It has a profile similar to lidocaine but with less neurotoxicity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 18 to 65 years.
- •Both Sexes.
- •American Society of Anesthesiologists (ASA) physical status I-II.
- •Normal body mass index (BMI) 18-
- •Undergoing cystoscopic procedure under spinal anesthesia.
排除标准
- •- Patient's refusal.
- •History of allergy to local anesthetics (hyperbaric prilocaine or hyperbaric bupivacaine).
- •History of impaired gait before the study.
- •Contraindications to SA including :-
- •Coagulopathy.
- •Elevated intracranial pressure (ICP).
- •Infection at the site.
- •Spinal cord disorder.
- •Severe hypovolemia.
- •Uncontrolled hypertension systolic ≥ 140 mmHg or diastolic ≥ 90 mmHg.
- •Uncontrolled Diabetes mellitus HbA1c ≥ 8.5%
研究者
Mohamed Magdy Desouky
Resident of Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, Helwan University, Egypt.
Helwan University