NCT02173132已完成3 期
Acetyl-L-Carnitine Reduces Perceived Work Stress and Improves Work Ability and Work Performance in Hepatic Encephalopathy
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 94
- 试验地点
- 1
- 主要终点
- work stress
研究概览
简要总结
This study evaluated the effects of acetyl-L-carnitine treatment on Perceived Work Stress, Work Ability and Work Performance in subjects with Hepatic Encephalopathy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 33 Years 至 68 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •overt hepatic encephalopathy (HE) or a history of overt HE
排除标准
- •history of recent alcohol intake; infection; recent antibiotic use or gastrointestinal bleeding; history of recent use of drugs affecting psychometric performances like benzodiazepines, antiepileptics or psychotropic drugs; a history of shunt surgery or transjugular intrahepatic portosystemic shunt for portal hypertension; electrolyte imbalance; renal impairment; hepatocellular carcinoma; severe medical problems such as congestive heart failure, pulmonary disease or neurological or psychiatric disorder that could influence quality of life measurement; inability to perform neuropsycological tests.
研究组 & 干预措施
acetyl-L-carnitine
Active Comparator
2 g acetyl-L carnitine twice a day for 90 days
干预措施: Acetyl-L-carnitine (Drug)
sugar pill
Placebo Comparator
Placebo twice a day for 90 days
干预措施: Placebo (Other)
结局指标
主要结局
work stress
时间窗: 90 days
次要结局
未报告次要终点
研究者
Mariano Malaguarnera
Associate Professor
University of Catania
研究点 (1)
Loading locations...
相似试验
Enrolling By Invitation
不适用
Neurobiological Effects of Work-related Adjustment DisorderAdjustment Disorder With Work InhibitionNCT03334045Odense University Hospital82
已完成
不适用
Randomized controlled trial to reduce stressAJPRN-UMIN000023903Suntory Global Innovation Center Ltd.90
已完成
4 期
Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α2b Plus RibavirinWork Productivity and Activity Impairment in Workers With Chronic C HepatitisFatigue in Workers With Chronic C HepatitisFatigueNCT01913964University of Catania
已完成
不适用
Decreasing employees’ work stress by a participatory, organizational level intervention in primary educatioWork stress, job satisfaction, job demands and resourcesISRCTN14697835TNO119
已完成
不适用
Oral Acetyl-L-Carnitine Therapy Reduces Fatigue In Hepatic EncephalopathyHepatic EncephalopathyNCT01223742University of Catania