Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.

Shanghai Mental Health Center1 site in 1 country60 target enrollmentSeptember 2016

ConditionsTardive Dyskinesia

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Tardive Dyskinesia
Sponsor: Shanghai Mental Health Center
Enrollment: 60
Locations: 1
Primary Endpoint: Change from baseline in motor evoked potential(MEP)
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to explore the therapeutic effect and mechanism of transcranial magnetic stimulation (rTMS) in the treatment of the tardive dyskinesia.

Detailed Description

The study was a parallel control design trial for 2 weeks. Patients with schizophrenia were treated with 10-Hz rTMS on left motor cortex (added to the ongoing treatment). Clinical symptoms and MEP were assessment before and after rTMS treatment.

Registry

clinicaltrials.gov

Start Date

September 2016

End Date

December 2018

Last Updated

8 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Shanghai Mental Health Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•The diagnosis of schizophrenia according to DSM-IV；
•At least two item of Abnormal Involuntary Movement Scale（AIMS） must be 2 points or higher
•these symptoms are not from Parkinson，tourette's syndrome,huntington disease
•Signed an informed consent

Exclusion Criteria

•rTMS contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure
•patients to be diagnosed according to DSM-IV for substance abused, development delayed
•current treatment with anticonvulsant acting drugs such as anticonvulsants, benzodiazepines
•Acute risk of suicide and impulse
•history of epileptic seizures or the presence of epileptic activity documented on the basis of EEG
•pregnant and lactant women

Outcomes

Primary Outcomes

Change from baseline in motor evoked potential(MEP)

Time Frame: 2 times (Before treatment,immediately after treatment)

Change from baseline in Abnormal Involuntary Movement Scale(AIMS）

Time Frame: 2 times (Before treatment,immediately after treatment)

Secondary Outcomes

Change from baseline in Barnes Akathisia Rating Scale（BARS）(2 times (Before treatment,immediately after treatment))
Change from baseline in Simpson-Angus Scale（SAS）(2 times (Before treatment,immediately after treatment))
Change from baseline in cortical silent period(2 times (Before treatment,immediately after treatment))
Change from baseline in clinical global impression (CGI)(2 times (Before treatment,immediately after treatment))
Change from baseline in short interval intracortical inhibition(SICI）(2 times (Before treatment,immediately after treatment))
Change from baseline in intracortical facilitation(ICF）(2 times (Before treatment,immediately after treatment))
Change from baseline in Positive and Negative Syndrome Scale（PANSS）(2 times (Before treatment,immediately after treatment))