Comparison of the Bilateral Transversus Abdominis Plane (TAP) Block Versus Curare in Muscle Relaxation of the Abdominal Wall During Laparoscopic Digestive Surgery: Prospective Randomized Study

Centre Hospitalier Universitaire, Amiens1 site in 1 country60 target enrollmentJune 1, 2012

ConditionsThe Main of This Study is to Compare the Nerve Block of the Muscles of the Abdominal Wall Between the Bilateral TAP Block and Curare

InterventionsTransversus Abdominis Plane Curare

DrugsTransversus Abdominis Plane Curare

Overview

Phase: Phase 4
Intervention: Transversus Abdominis Plane
Conditions: The Main of This Study is to Compare the Nerve Block of the Muscles of the Abdominal Wall Between the Bilateral TAP Block and Curare
Sponsor: Centre Hospitalier Universitaire, Amiens
Enrollment: 60
Locations: 1
Primary Endpoint: Muscle relaxation.
Status: Completed
Last Updated: 5 months ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

This is a Biomedical Research, prospective, randomized, controlled single-blind mono centric, phase IV comparison trial of the bilateral TAP block versus curare in muscle relaxation of the abdominal wall during laparoscopic digestive surgery.

Registry

clinicaltrials.gov

Start Date

June 1, 2012

End Date

January 2013

Last Updated

5 months ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Centre Hospitalier Universitaire, Amiens

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients older than 18 years and under 75 years
•Informed consent signed
•ASA I, II and III
•Patient affiliated to social security

Exclusion Criteria

•BMI\> 35 kg / m
•Personal or family history of malignant hyperthermia
•History of allergy or hypersensitivity to intravenous anesthetics (remifentanil), local anesthetics or muscle relaxants
•Contraindications to sevoflurane: a history of malignant hyperthermia, history of liver disease after sevoflurane anesthesia, halogenated agents or hypersensitivity to any of these components.
•Contraindications to succinylcholine: hyperkalemia, plasma cholinesterase deficiency nickname, para or tetraplegia more than 24 hours, burns over 24
•Contraindications to cisatracurium: myasthenia
•Neuromuscular diseases
•Contraindications to local anesthetics: hypersensitivity to local anesthetics of the amide, intravenous regional anesthesia, porphyria, ventricular atrial conduction disturbances, epilepsy uncontrolled by treatment
•Pregnancy and lactation
•severe coagulation disorders

Arms & Interventions

TAP

Intervention: Transversus Abdominis Plane

curare

Patients will be randomized into two parallel groups. One group will receive curare, another benefit of a bilateral TAP block

Intervention: Curare

Outcomes

Primary Outcomes

Muscle relaxation.

Time Frame: 20 minutes after anesthesia induction

Muscle relaxation of the abdominal wall will be evaluated based on the amount of volume infused initially to create the pneumoperitoneum. This parameter is given by the unit of laparoscopy and allow us to calculate the abdominal compliance (C = ΔV / Ap).