Low Dose (1mcg ) ACTH Stimulation Test for Assessment of the Hypothalamo- Pituitary- Adrenal Axis in Patients Treated With Intravitreal Injection of Triamcinolone Acetonide
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Secondary Adrenal Insufficiency
- Sponsor
- HaEmek Medical Center, Israel
- Enrollment
- 28
- Locations
- 1
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The use of intravitreal corticosteroids in the management ocular inflammatory diseases has recently gained widespread acceptance. The purpose of this study is to determine if the use of intravitreal triamcinolone is associated with suppression of endogenous cortisol production, as generally admitted for patients treated with oral or parenteral corticosteroid therapy.
Detailed Description
The normalcy of hypothalamic- pituitary- adrenal axis (HPA axis) of enrolled subjects will will be assessed before intravitreal injection of 4mg of triamcinolone and again after one day, one week and two weeks. Patients with abnormal HPA axis will be re-tested after four weeks and later until the HPA axis function return to normal. The HPA axis will be assessed with low dose (1mcg) intravenous corticotropin(ACTH) stimulation test, in which cortisol levels will be sampled before , 30 minutes and 60 minutes after 1mcg ACTH IV injection.
Investigators
avraham ishay
Dr
HaEmek Medical Center, Israel
Eligibility Criteria
Inclusion Criteria
- •patients receiving intravitreous injection of triamcinolone 4mg
Exclusion Criteria
- •patients receiving steroids in any form, except by intravitreous administration
Outcomes
Primary Outcomes
Not specified