A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Phase 3

Active, not recruiting

• Conditions: Metastatic Castration-sensitive Prostate Cancer
• Interventions: Drug: Niraparib; Drug: Abiraterone acetate (AA); Drug: Prednisone; Drug: Placebo for Niraparib

• Registration Number: NCT04497844
• Lead Sponsor: Janssen Research & Development, LLC

Brief Summary

The purpose of the study is to determine if the combination of niraparib with Abiraterone Acetate (AA) plus prednisone compared with AA plus prednisone in participants with deleterious germline or somatic Homologous Recombination Repair (HRR) gene-mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) provides superior efficacy in improving radiographic progression-free survival (rPFS).

Detailed Description

Prostate cancer is a heterogenous disease and recent genomic analyses have highlighted specific germline and somatic mutations and alternative driver growth signaling pathways in patients with metastatic disease. Abiraterone acetate plus prednisone (AAP) is an established standard of care for the treatment of participants with mCSPC and is included in widely accepted clinical treatment guidelines. Niraparib in combination with AAP has been approved for the treatment of BRCA-mutated Metastatic Castration-Resistant Prostate Cancer (mCRPC). Niraparib is an investigational agent in the Metastatic Castration-Sensitive Prostate Cancer (mCSPC) population. Whether the addition of niraparib to the AAP standard of care may improve initial disease control and long-term outcomes compared with AAP alone in a biomarker selected mCSPC population is being evaluated on this trial. The study will consist of 4 phases; a Prescreening Phase for biomarker evaluation for eligibility only, a Screening Phase, a Treatment Phase, and a Follow-up Phase. Efficacy evaluations include the following: tumor measurements by computed tomography (CT), magnetic resonance imaging (MRI; abdomen, chest, and pelvis), Technetium-99m (99mTc) bone scans, serum prostate sensitive antigen (PSA) evaluations, and patient reported outcomes (PROs). Safety evaluations include incidence of adverse events and clinical laboratory parameters.

Study Timeline

• Study First Submitted: 2020-07-31
• Study First Submitted QC: 2020-07-31
• Study First Posted: 2020-08-04
• Study Start: 2020-09-23
• Primary Completion: 2025-01-07
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-22
• Last Update Posted: 2025-05-23
• Study Completion: 2027-11-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: Male
• Target Recruitment: 696

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Niraparib with Abiraterone Acetate plus Prednisone (AAP)	Niraparib	Participants will receive the following in each 28-day treatment cycle: niraparib 200 milligrams (mg), abiraterone acetate (AA) 1000 mg plus prednisone 5 mg once daily.
Niraparib with Abiraterone Acetate plus Prednisone (AAP)	Prednisone	Participants will receive the following in each 28-day treatment cycle: niraparib 200 milligrams (mg), abiraterone acetate (AA) 1000 mg plus prednisone 5 mg once daily.
Niraparib with Abiraterone Acetate plus Prednisone (AAP)	Abiraterone acetate (AA)	Participants will receive the following in each 28-day treatment cycle: niraparib 200 milligrams (mg), abiraterone acetate (AA) 1000 mg plus prednisone 5 mg once daily.
AA plus Prednisone (AAP)	Abiraterone acetate (AA)	Participants will receive the following in each 28-day treatment cycle: matching placebo for Niraparib along with AA 1000 mg plus prednisone 5 mg once daily.
AA plus Prednisone (AAP)	Prednisone	Participants will receive the following in each 28-day treatment cycle: matching placebo for Niraparib along with AA 1000 mg plus prednisone 5 mg once daily.
AA plus Prednisone (AAP)	Placebo for Niraparib	Participants will receive the following in each 28-day treatment cycle: matching placebo for Niraparib along with AA 1000 mg plus prednisone 5 mg once daily.

Primary Outcome Measures

Name	Time	Method
Radiographic Progression-free Survival (rPFS)	Up to 47 months	rPFS is defined as time from randomization date to date of radiographic progression or death, whichever occurs first. Radiographic progression will be evaluated by Prostate Cancer Working Group 3 (PCWG3) criteria and Response Evaluation Criteria in Solid Tumors (RECIST 1.1).

Secondary Outcome Measures

Name	Time	Method
Overall Survival (OS)	Up to 78 months	OS is defined as the time from date of randomization to date of death from any cause.
Time to Symptomatic Progression	Up to 47 months	Time to symptomatic progression is defined as time from the date of randomization to the date of any of the following (whichever occurs first): a) the use of external beam radiation therapy for skeletal or pelvic symptoms; b) the need for tumor-related orthopedic surgical intervention; c) other cancer-related procedures; d) cancer-related morbid events; e) initiation of a new systemic anti-cancer therapy because of cancer symptoms.
Time to Subsequent Therapy	Up to 47 months	Time to Subsequent Therapy is defined as the time from date of randomization to the date of initiation of subsequent therapy for prostate cancer.
Number of Participants with Adverse Events as a Measure of Safety and Tolerability	Up to 78 months	An adverse event (AE) is any untoward medical occurrence in a clinical study participant administered a medicinal (investigational or non investigational) product. AE does not necessarily have a causal relationship with intervention.

Trial Locations

Locations (385)

Liga Norte Riograndense Contra O Cancer; 🇧🇷 Natal, Brazil

UPCO Unidade de Pesquisa Clinica em Oncologia; 🇧🇷 Pelotas, Brazil

Irmandade Santa Casa de Misericordia de Porto Alegre; 🇧🇷 Porto Alegre, Brazil

Hospital Ernesto Dornelles; 🇧🇷 Porto Alegre, Brazil

MultiHemo Servicos Medicos S.A; 🇧🇷 Recife, Brazil

Ministerio da Saude Instituto Nacional do Cancer; 🇧🇷 Rio de Janeiro, Brazil

Universidade do Estado do Rio de Janeiro - UERJ; 🇧🇷 Rio de Janeiro, Brazil

Oncoclinicas Rio de Janeiro S A; 🇧🇷 Rio de Janeiro, Brazil

Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI); 🇧🇷 Rio de Janeiro, Brazil

Nucleo de Oncologia da Bahia; 🇧🇷 Salvador, Brazil

Hospital Sao Rafael; 🇧🇷 Salvador, Brazil

Fundacao do ABC Centro Universitario FMABC; 🇧🇷 Santo Andre, Brazil

Irmandade Santa Casa de Misericordia de Sao Paulo; 🇧🇷 Sao Paulo, Brazil

Instituto de Ensino e Pesquisa São Lucas; 🇧🇷 Sao Paulo, Brazil

Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo; 🇧🇷 Sao Paulo, Brazil

Real e Benemerita Associacao Portuguesa de Beneficencia; 🇧🇷 Sao Paulo, Brazil

Beijing Hospital; 🇨🇳 Beijing, China

West China Hospital of Sichuan University; 🇨🇳 Chengdu, China

Sichuan Provincial Peoples Hospital; 🇨🇳 Chengdu, China

Western Theater General Hospital of the Chinese People's Liberation Army; 🇨🇳 Chengdu, China

Chongqing University Cancer Hospital; 🇨🇳 Chongqing, China

Southwest Hospital, The Third Military Medical University; 🇨🇳 Chongqing, China

Sun Yat Sen University Cancer Center; 🇨🇳 GuangZhou, China

Guangzhou First Municipal People's Hospital; 🇨🇳 Guangzhou, China

Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University; 🇨🇳 Guangzhou, China

Zhejiang Provincial People's Hospital; 🇨🇳 Hangzhou, China

The First Affiliated Hospital of NanChang University; 🇨🇳 Nanchang, China

Jiangsu Province Cancer Hospital; 🇨🇳 Nanjing, China

Nanjing Drum Tower Hospital; 🇨🇳 Nanjing, China

The First Affiliated Hospital of Ningbo University; 🇨🇳 Ningbo, China

Urologica Praktyka Lekarska Adam Marcheluk; 🇵🇱 Siedlce, Poland

Hosp Clinic de Barcelona; 🇪🇸 Barcelona, Spain

Hosp. Gral. Univ. de Castellon; 🇪🇸 Castellon, Spain

Institut Català D'Oncologia Girona; 🇪🇸 Girona, Spain

Hosp. de Jerez de La Frontera; 🇪🇸 Jerez de la Frontera, Spain

Hosp. Univ. de La Princesa; 🇪🇸 Madrid, Spain

Hosp. Univ. Ramon Y Cajal; 🇪🇸 Madrid, Spain

Hosp. Univ. 12 de Octubre; 🇪🇸 Madrid, Spain

Hosp. Univ. La Paz; 🇪🇸 Madrid, Spain

Hosp. Univ. Hm Monteprincipe; 🇪🇸 Madrid, Spain

Hosp Virgen de La Victoria; 🇪🇸 Málaga, Spain

Corporacio Sanitari Parc Tauli; 🇪🇸 Sabadell, Spain

Hosp. Univ. Marques de Valdecilla; 🇪🇸 Santander, Spain

Hosp. Virgen Del Rocio; 🇪🇸 Sevilla, Spain

Hosp. Clinico Univ. de Valencia; 🇪🇸 Valencia, Spain

Salgrenska University hospital; 🇸🇪 Göteborg, Sweden

Urologiska Mottagningen; 🇸🇪 Malmö, Sweden

Sodersjukhuset; 🇸🇪 Stockholm, Sweden

Karolinska Universitetssjukhuset Solna; 🇸🇪 Stockholm, Sweden

Urology Centers Of Alabama; 🇺🇸 Homewood, Alabama, United States

Mayo Clinic Arizona; 🇺🇸 Phoenix, Arizona, United States

Urological Associates of Southern Arizona, P.C.; 🇺🇸 Tucson, Arizona, United States

Greater Los Angeles VA Healthcare System; 🇺🇸 Los Angeles, California, United States

University of California Irvine Medical Center Chao Family Comprehensive Cancer Center; 🇺🇸 Orange, California, United States

San Bernardino Urological Associates; 🇺🇸 San Bernardino, California, United States

University of San Francisco California; 🇺🇸 San Francisco, California, United States

Rocky Mountain Cancer Centers; 🇺🇸 Colorado Springs, Colorado, United States

AdventHealth Medical Group Urology of Denver; 🇺🇸 Denver, Colorado, United States

Colorado Clinical Research; 🇺🇸 Lakewood, Colorado, United States

Eastern Connecticut Hematology & Oncology Assoc.; 🇺🇸 Norwich, Connecticut, United States

Advanced Urology Institute; 🇺🇸 Daytona Beach, Florida, United States

Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center; 🇺🇸 Fort Lauderdale, Florida, United States

University of Florida Health Jacksonville; 🇺🇸 Jacksonville, Florida, United States

Cancer Specialists of North Florida; 🇺🇸 Jacksonville, Florida, United States

Urology of Indiana; 🇺🇸 Greenwood, Indiana, United States

First Urology; 🇺🇸 Jeffersonville, Indiana, United States

Medisport; 🇵🇱 Lublin, Poland

Ochsner Clinic Foundation; 🇺🇸 New Orleans, Louisiana, United States

Baltimore VA Medical Center; 🇺🇸 Baltimore, Maryland, United States

Maryland Oncology Hematology, PA; 🇺🇸 Columbia, Maryland, United States

Chesapeake Urology Associates; 🇺🇸 Towson, Maryland, United States

Michigan Institute of Urology; 🇺🇸 Troy, Michigan, United States

Mosaic Life Care; 🇺🇸 Saint Joseph, Missouri, United States

St. Louis VA Medical Center; 🇺🇸 Saint Louis, Missouri, United States

GU Research Network; 🇺🇸 Omaha, Nebraska, United States

New York Oncology Hematology; 🇺🇸 Albany, New York, United States

Montefiore Medical Center; 🇺🇸 Bronx, New York, United States

Manhattan VAMC; 🇺🇸 New York, New York, United States

Mount Sinai; 🇺🇸 New York, New York, United States

Memorial Sloan Kettering Cancer Center; 🇺🇸 New York, New York, United States

Associated Medical Professionals; 🇺🇸 Syracuse, New York, United States

Durham VAMC; 🇺🇸 Durham, North Carolina, United States

Stephenson Cancer Center; 🇺🇸 Oklahoma City, Oklahoma, United States

VA Portland Health Care System; 🇺🇸 Portland, Oregon, United States

Oregon Oncology Specialists; 🇺🇸 Salem, Oregon, United States

Keystone Urology Specialists; 🇺🇸 Lancaster, Pennsylvania, United States

Philadelphia VA Medical Center; 🇺🇸 Philadelphia, Pennsylvania, United States

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States

University of Pittsburgh Medical Center (UPMC); 🇺🇸 Pittsburgh, Pennsylvania, United States

Ralph H. Johnson Veterans Affairs Medical Center; 🇺🇸 Charleston, South Carolina, United States

Prisma Health; 🇺🇸 Seneca, South Carolina, United States

Urology Associates; 🇺🇸 Nashville, Tennessee, United States

Texas Oncology-Austin; 🇺🇸 Austin, Texas, United States

Texas Oncology - Northeast; 🇺🇸 Tyler, Texas, United States

Houston Metro Urology; 🇺🇸 Houston, Texas, United States

Texas Oncology P A; 🇺🇸 New Braunfels, Texas, United States

University of Utah Huntsman Cancer Institute; 🇺🇸 Salt Lake City, Utah, United States

Virginia Oncology Associates; 🇺🇸 Norfolk, Virginia, United States

Virginia Commonwealth University - Massey Cancer Center; 🇺🇸 Richmond, Virginia, United States

VA Puget Sound Healthcare System; 🇺🇸 Seattle, Washington, United States

Seattle Cancer Care Alliance; 🇺🇸 Seattle, Washington, United States

MultiCare Health System; 🇺🇸 Tacoma, Washington, United States

Sociedade Beneficente de Senhoras Hospital Sirio Libanes; 🇦🇷 Buenos Aires, Argentina

Centro Oncológico Korben; 🇦🇷 Buenos Aires, Argentina

Hospital Militar Cosme Argerich; 🇦🇷 C.a.b.a., Argentina

CINME Centro de Investigaciones Metabolicas; 🇦🇷 Caba, Argentina

CIPREC Arenales; 🇦🇷 Caba, Argentina

Centro de Urologia (CDU); 🇦🇷 Ciudad Automoma Buenos Aires, Argentina

Hospital Italiano de Buenos Aires; 🇦🇷 Ciudad Autonoma de, Argentina

Clinica Adventista Belgrano; 🇦🇷 Ciudad De Buenos Aires, Argentina

Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica; 🇦🇷 Cordoba, Argentina

Centro Urologico Profesor Bengio; 🇦🇷 Cordoba, Argentina

Instituto Médico de Río Cuarto; 🇦🇷 Cordoba, Argentina

Hospital Privado de Cordoba; 🇦🇷 Cordoba, Argentina

Hospital Privado de Comunidad; 🇦🇷 Mar Del Plata, Argentina

Centro de Investigacion Pergamino SA; 🇦🇷 Pergamino, Argentina

ARS Médica; 🇦🇷 San Salvador De Jujuy, Argentina

Sunshine Coast University Hospital; 🇦🇺 Birtinya, Australia

St Vincent s Hospital Sydney; 🇦🇺 Darlinghurst, Australia

Cancer Care Services Clinical Research Unit; 🇦🇺 Herston, Australia

Royal Hobart Hospital; 🇦🇺 Hobart, Australia

Icon Cancer Centre Kurralta Park; 🇦🇺 Kurralta Park, Australia

Liverpool Hospital; 🇦🇺 Liverpool, Australia

Peter MacCallum Cancer Centre; 🇦🇺 Melbourne, Australia

Fiona Stanley Hospital; 🇦🇺 Murdoch, Australia

Macquarie University Hospital; 🇦🇺 North Ryde, Australia

ICON Cancer Care; 🇦🇺 South Brisbane, Australia

St John of God Subiaco Hospital; 🇦🇺 Subiaco, Australia

Bobruisk Interregional Oncology Dispensary; 🇧🇾 Bobruisk, Belarus

Brest Regional Oncology Dispensary; 🇧🇾 Brest, Belarus

Gomel Regional Clinical Oncology Dispensary; 🇧🇾 Gomel, Belarus

Grodno University Hospital; 🇧🇾 Grodno, Belarus

N N Alexandrov National Cancer Centre of Belarus; 🇧🇾 Lesnoy, Belarus

Minsk city Clinical Oncological Dispensary; 🇧🇾 Minsk, Belarus

Mogilev Regional Oncology Dispensary; 🇧🇾 Mogilev, Belarus

Vitebsk Regional Clinical Oncology Dispensary; 🇧🇾 Vitebsk, Belarus

ZNA Middelheim; 🇧🇪 Antwerp, Belgium

Grand Hopital De Charleroi Site Les Viviers; 🇧🇪 Charleroi, Belgium

Jolimont; 🇧🇪 Haine-St-Paul, Belgium

CHC MontLegia; 🇧🇪 Liege, Belgium

CHU UCL Namur - Site Sainte Elisabeth; 🇧🇪 Namur, Belgium

Clinique St Pierre; 🇧🇪 Ottignies, Belgium

Algemeen Ziekenhuis Delta; 🇧🇪 Roeselare, Belgium

GZA Ziekenhuizen; 🇧🇪 Wilrijk, Belgium

Fundacao Pio XII; 🇧🇷 Barretos, Brazil

Cetus Oncologia; 🇧🇷 Belo Horizonte, Brazil

PERSONAL Oncologia de Precisao e Personalizada; 🇧🇷 Belo Horizonte, Brazil

CIONC Centro Integrado de Oncologia de Curitiba; 🇧🇷 Curitiba, Brazil

Centro de Pesquisa e Ensino em Oncologia de Santa Catarina CEPEN; 🇧🇷 Florianopolis, Brazil

Pronutrir; 🇧🇷 Fortaleza, Brazil

Associacao de Combate ao Cancer em Goias - Hospital de Cancer Araujo Jorge; 🇧🇷 Goiania, Brazil

Fundacao Sao Francisco Xavier; 🇧🇷 Ipatinga, Brazil

Instituto Joinvilense de Hematologia e Oncologia Ltda Centro de Hematologia e Oncologia; 🇧🇷 Joinville, Brazil

Hospital Alemao Oswaldo Cruz; 🇧🇷 Sao Paulo, Brazil

Instituto de Assistencia Medica ao Servidor Publico Estadual IAMSPE; 🇧🇷 Sao Paulo, Brazil

IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado; 🇧🇷 Sorocaba, Brazil

Instituto do Cancer Arnaldo Vieira de Carvalho; 🇧🇷 São Paulo, Brazil

Núcleo de Pesquisa São Camilo; 🇧🇷 São Paulo, Brazil

Centro Oncológico do Triângulo; 🇧🇷 Uberlândia, Brazil

MHAT Deva Maria; 🇧🇬 Burgas, Bulgaria

UMHAT 'Dr. Georgi Stranski', EAD; 🇧🇬 Pleven, Bulgaria

Complex Oncology Center - Plovdiv EOOD; 🇧🇬 Plovdiv, Bulgaria

Multifunctional Hospital for Active Treatment for Women Health Nadezhda; 🇧🇬 Sofia, Bulgaria

Specialized Hospital for Active Treatment in Oncology; 🇧🇬 Sofia, Bulgaria

UMHAT Sofia Med; 🇧🇬 Sofia, Bulgaria

Comprehensive Cancer Center; 🇧🇬 Vratsa, Bulgaria

Prostate Cancer Centre; 🇨🇦 Calgary, Alberta, Canada

Cross Cancer Institute; 🇨🇦 Edmonton, Alberta, Canada

British Columbia Cancer Agency(BCCA)-Sindi Ahluwalia Hawkins Centre for the Southern Interior(CSI); 🇨🇦 Kelowna, British Columbia, Canada

British Columbia Cancer Agency BCCA Vancouver Centre; 🇨🇦 Vancouver, British Columbia, Canada

British Columbia Cancer Agency Vancouver Island Centre; 🇨🇦 Victoria, British Columbia, Canada

McMaster Institute of Urology; 🇨🇦 Hamilton, Ontario, Canada

Kingston Health Sciences Centre, Kingston General Health Research Institute; 🇨🇦 Kingston, Ontario, Canada

Sunnybrook Health Sciences Center; 🇨🇦 Toronto, Ontario, Canada

Princess Margaret Cancer Centre University Health Network; 🇨🇦 Toronto, Ontario, Canada

Centre Hospitalier de l'Universite de Montreal; 🇨🇦 Montreal, Quebec, Canada

McGill University - Jewish General Hospital; 🇨🇦 Montreal, Quebec, Canada

Cancer Hospital Chinese Academy of Medical Sciences; 🇨🇳 Beijing, China

Peking University First Hospital; 🇨🇳 Beijing, China

Beijing Friendship Hospital Capital Medical University; 🇨🇳 Beijing, China

Beijing Cancer Hospital; 🇨🇳 Beijing, China

Beijing University Third Hospital; 🇨🇳 Beijing, China

Fudan University Shanghai Cancer Center; 🇨🇳 Shanghai, China

Huashan Hospital Fudan University; 🇨🇳 Shanghai, China

Renji Hospital Affiliated to Medical College of Shanghai Jiaotong University; 🇨🇳 Shanghai, China

The Fifth People's Hospital of Shanghai, Fudan University; 🇨🇳 Shanghai, China

Huadong Hospital Affiliated to Fudan University; 🇨🇳 Shanghai, China

Shengjing Hospital Of China Medical University; 🇨🇳 Shenyang, China

Second Affiliated Hospital of Soochow University; 🇨🇳 SuZhou, China

The First Affliated Hospital of Soochow University; 🇨🇳 Suzhou, China

The First Affiliated Hospital of Wenzhou Medical University; 🇨🇳 Wenzhou, China

TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology; 🇨🇳 Wuhan, China

The First Affiliated Hospital of Xian Jiaotong University; 🇨🇳 XI An, China

Fakultni nemocnice u sv. Anny v Brne; 🇨🇿 Brno, Czechia

FN Hradec Kralove, Urologicka klinika; 🇨🇿 Hradec Kralove, Czechia

Krajská nemocnice Liberec; 🇨🇿 Liberec, Czechia

Uromedical Center s.r.o.; 🇨🇿 Olomouc, Czechia

Urologicka klinika 1 LF UK a VFN; 🇨🇿 Praha 2, Czechia

Aalborg University Hospital; 🇩🇰 Aalborg, Denmark

Copenhagen University Hospital; 🇩🇰 Copenhagen, Denmark

Herlev Hospital; 🇩🇰 Herlev, Denmark

Næstved Hospital; 🇩🇰 Naestved, Denmark

Odense Universitetshospital; 🇩🇰 Odense, Denmark

Vejle Hospital; 🇩🇰 Vejle, Denmark

Institut de Cancerologie de l Ouest ICO; 🇫🇷 Angers Cedex 9, France

Institut Sainte Catherine; 🇫🇷 Avignon Cedex 9, France

CHRU De Besancon; 🇫🇷 Besancon, France

Institut Bergonie; 🇫🇷 Bordeaux, France

Centre Jean Perrin; 🇫🇷 Clermont Ferrand, France

Centre Georges Francois Leclerc; 🇫🇷 Dijon, France

Centre Oscar Lambret; 🇫🇷 Lille, France

Centre Leon Berard; 🇫🇷 Lyon, France

Hopital Prive Jean Mermoz; 🇫🇷 Lyon, France

Institut Regional du Cancer de Montpellier Val d'Aurelle; 🇫🇷 Montpellier, France

Polyclinique de Gentilly; 🇫🇷 Nancy, France

CHU De Poitiers; 🇫🇷 Poitiers Cedex, France

Centre Hopitalier Inter-Communal De Cornouaille; 🇫🇷 Quimper, France

HIA Begin; 🇫🇷 Saint Mande, France

Institut de Cancérologie de Loire; 🇫🇷 Saint-Priest-en-Jarez, France

Clinique Sainte Anne; 🇫🇷 Strasbourg, France

Hopital Foch; 🇫🇷 Suresnes, France

CHRU de Tours; 🇫🇷 Tours, France

Städtisches Klinikum Braunschweig gGmbH - Standort Salzdahlumer; 🇩🇪 Braunschweig, Germany

Universitätsklinik Carl Gustav Carus, Med. Klinik u. Poliklinik I; 🇩🇪 Dresden, Germany

Urologicum Duisburg; 🇩🇪 Duisburg, Germany

Medizinische Hochschule Hannover; 🇩🇪 Hannover, Germany

Universitaetsklinikum Koelnt; 🇩🇪 Koeln, Germany

Universitaetsklinikum Muenster; 🇩🇪 Muenster, Germany

Klinikum rechts der Isar - III. Med. Klinik und Poliklinik; 🇩🇪 München, Germany

Studienpraxis Urologie Drs. Feyerabend; 🇩🇪 Nuertingen, Germany

Jahn Ferenc Del-pesti Korhaz es Rendelointezet; 🇭🇺 Budapest, Hungary

Debreceni Egyetem; 🇭🇺 Debrecen, Hungary

Petz Aladar Megyei Oktato Korhaz; 🇭🇺 Gyor, Hungary

Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz; 🇭🇺 Gyula, Hungary

Borsod Abauj Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktato Korhaz; 🇭🇺 Miskolc, Hungary

Szegedi Tudomanyegyetem; 🇭🇺 Szeged, Hungary

Szent Borbala Hospital Tatabanya; 🇭🇺 Tatabanya, Hungary

Haemek Medical Center - Afula; 🇮🇱 Afula, Israel

Soroka Hospital; 🇮🇱 Beer-Sheva, Israel

Rambam Medical Center; 🇮🇱 Haifa, Israel

Hadassah Hospital; 🇮🇱 Jerusalem, Israel

Rabin Medical Center, Beilinson Hospital; 🇮🇱 Petach Tikvah, Israel

Sheba Medical Center Tel Hashomer; 🇮🇱 Ramat Gan, Israel

Tel Aviv Sourasky Medical Center; 🇮🇱 Tel-Aviv, Israel

Ospedale S. Donato - Asl 8 Arezzo; 🇮🇹 Arezzo, Italy

Divisione di Oncologia - Istituto per la ricerca e cura del cancro; 🇮🇹 Candiolo, Italy

Istituti Ospitalieri di Cremona, AO di Cremona; 🇮🇹 Cremona, Italy

Azienda Ospedaliera ''Vito Fazzi''; 🇮🇹 Lecce, Italy

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori; 🇮🇹 Meldola, Italy

Ospedale San Raffaele; 🇮🇹 Milano, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori; 🇮🇹 Milano, Italy

European Institute of Oncology; 🇮🇹 Milano, Italy

Fondazione G Pascale Istituto Nazionale Tumori IRCCS; 🇮🇹 Napoli, Italy

Aou San Luigi Gonzaga; 🇮🇹 Orbassano, Italy

Istituto Oncologico Veneto Iov Irccs Padova; 🇮🇹 Padova, Italy

Azienda Ospedaliero Universitaria Pisana; 🇮🇹 Pisa, Italy

ASL Napoli 2 Nord-SM delle Grazie Hospital; 🇮🇹 Pozzuoli, Italy

Casa Sollievo Della Sofferenza IRCCS; 🇮🇹 San Giovanni Rotondo, Italy

Ospedale S. Chiara; 🇮🇹 Trento, Italy

Ospedale San Bortolo; 🇮🇹 Vicenza, Italy

Pusan National University Hospital; 🇰🇷 Busan, Korea, Republic of

Kyungpook National University Chilgok Hospital; 🇰🇷 Daegu, Korea, Republic of

Keimyung University Dongsan Hospital; 🇰🇷 Daegu, Korea, Republic of

Chungnam National University Hospital; 🇰🇷 Daejeon, Korea, Republic of

Chonnam National University Hospital; 🇰🇷 Gwangju, Korea, Republic of

National Cancer Center; 🇰🇷 Gyeonggi-do, Korea, Republic of

Ajou University Hospital; 🇰🇷 Gyeonggi-do, Korea, Republic of

Seoul National University Bundang Hospital; 🇰🇷 Seongnam-si, Korea, Republic of

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of

Severance Hospital Yonsei University Health System; 🇰🇷 Seoul, Korea, Republic of

Asan Medical Center; 🇰🇷 Seoul, Korea, Republic of

Gangnam Severance Hospital, Yonsei University Health System; 🇰🇷 Seoul, Korea, Republic of

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of

The Catholic University of Korea Seoul St Mary s Hospital; 🇰🇷 Seoul, Korea, Republic of

Hospital Pulau Pinang; 🇲🇾 George Town, Malaysia

Hospital Sultan Ismail; 🇲🇾 Johor Bahru, Malaysia

Hospital Kuala Lumpur; 🇲🇾 Kuala Lumpur, Malaysia

University Malaya Medical Centre; 🇲🇾 Kuala Lumpur, Malaysia

Sarawak General Hospital; 🇲🇾 Kuching, Malaysia

Institut Kanser Negara Clinical Research Center; 🇲🇾 Putrajaya, Malaysia

Centro de Investigación Clínica Gramel S.C.; 🇲🇽 Ciudad de Mexico, Mexico

Consultorio de Especialidad en Urologia Privado; 🇲🇽 Durango, Mexico

Consultorio Privado; 🇲🇽 Zapopan, Mexico

Avix Investigacion Clinica S C; 🇲🇽 Monterrey, Mexico

i Can Oncology Center; 🇲🇽 Monterrey, Mexico

Oncologia Integral Satelite; 🇲🇽 Naucalpan, Mexico

Consultorio de Oncología Médica; 🇲🇽 Oaxaca, Mexico

Reinier de Graaf Gasthuis; 🇳🇱 Delft, Netherlands

Tergooiziekenhuizen; 🇳🇱 Hilversum, Netherlands

Canisius-Wilhelminaziekenhuis; 🇳🇱 Nijmegen, Netherlands

Elisabeth-TweeSteden Ziekenhuis; 🇳🇱 Tilburg, Netherlands

Auckland City Hospital; 🇳🇿 Auckland, New Zealand

Canterbury Urology Research Trust; 🇳🇿 Christchurch, New Zealand

Dunedin Hospital; 🇳🇿 Dunedin Central, New Zealand

Tauranga Hospital; 🇳🇿 Tauranga, New Zealand

IN VIVO Sp. z o.o; 🇵🇱 Bydgoszcz, Poland

Szpital Uniwersytecki NR 1 IM Dr Antoniego Jurasza; 🇵🇱 Bydgoszcz, Poland

Centrum Onkologii im Prof F Lukaszczyka; 🇵🇱 Bydgoszcz, Poland

Szpitale Pomorskie Sp z o o; 🇵🇱 Gdynia, Poland

Przychodnia Lekarska KOMED Roman Karaszewski; 🇵🇱 Konin, Poland

Klinika MedTrials; 🇵🇱 Krakow, Poland

Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi; 🇵🇱 Lodz, Poland

Szpital Grochowski Im Dr Med Rafala Masztaka Sp Z O O; 🇵🇱 Warszawa, Poland

Specjalistyczna przychodnia lekarska POLIMED; 🇵🇱 Wroclaw, Poland

Uls Almada Seixal - Hosp. Garcia de Orta; 🇵🇹 Almada, Portugal

Instituto Português de Oncologia Francisco Gentil - Centro Regional de Oncologia de Coimbra, S.A.; 🇵🇹 Coimbra, Portugal

Fund. Champalimaud; 🇵🇹 Lisboa, Portugal

Uls Santa Maria - Hosp. Santa Maria; 🇵🇹 Lisboa, Portugal

Puerto Rico Medical Research Center; 🇵🇷 Hato Rey, Puerto Rico

Altai Regional Oncology Dispensary; 🇷🇺 Barnaul, Russian Federation

Chelyabinsk Regional Clinical Center Of Oncology And Nuclear Medicine; 🇷🇺 Chelyabinsk, Russian Federation

Ivanovo Regional Oncology Dispensary; 🇷🇺 Ivanovo, Russian Federation

Moscow City Clinical Hospital # 62; 🇷🇺 Moscow, Russian Federation

Hertzen Oncology Research Institute; 🇷🇺 Moscow, Russian Federation

Privolzhsky District Medical Centre; 🇷🇺 Nizhny Novgorod, Russian Federation

Clinical Oncology Dispensary; 🇷🇺 Omsk, Russian Federation

LLC Novaya Clinica; 🇷🇺 Pyatigorsk, Russian Federation

Pyatigorsk Interdistrict Oncology Dispensary; 🇷🇺 Pyatigorsk, Russian Federation

Private Medical Institution Euromedservice; 🇷🇺 Saint Petersburg, Russian Federation

Leningrad Regional Oncology Dispensary; 🇷🇺 Saint-Petersburg, Russian Federation

Republican Oncology Dispensary; 🇷🇺 Saransk, Russian Federation

Tomsk Cancer Research Institute; 🇷🇺 Tomsk, Russian Federation

Multifunctional clinical medical center 'Medical city'; 🇷🇺 Tyumen, Russian Federation

Bashkir State Medical University; 🇷🇺 Ufa, Russian Federation

CancerCare Rondebosch; 🇿🇦 Cape Town, South Africa

Steve Biko Academic Hospital; 🇿🇦 Pretoria, South Africa

East Rand Urology Research Unit; 🇿🇦 Vosloorus, South Africa

Hosp Univ A Coruna; 🇪🇸 A Coruna, Spain

Hosp. de La Santa Creu I Sant Pau; 🇪🇸 Barcelona, Spain

Kaohsiung Chang Gung Memorial Hospital; 🇨🇳 Kaohsiung City, Taiwan

Kaohsiung Medical University Chung Ho Memorial Hospital; 🇨🇳 Kaohsiung, Taiwan

China Medical University Hospital; 🇨🇳 Taichung, Taiwan

Taichung Veterans General Hospital; 🇨🇳 Taichung, Taiwan

Tungs' Taichung MetroHarbor Hospital; 🇨🇳 Taichung, Taiwan

National Taiwan University Hospital.; 🇨🇳 Taipei, Taiwan

Taipei Veterans General Hospital; 🇨🇳 Taipei, Taiwan

Chang-Gung Memorial Hospital, LinKou Branch; 🇨🇳 Taoyuan, Taiwan

King Chulalongkorn Memorial Hospital; 🇹🇭 Bangkok, Thailand

Ramathibodi Hospital; 🇹🇭 Bangkok, Thailand

Siriraj Hospital; 🇹🇭 Bangkok, Thailand

Adana Baskent Yuregir Hospital; 🇹🇷 Adana, Turkey

Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital; 🇹🇷 Ankara, Turkey

Memorial Ankara Hastanesi; 🇹🇷 Ankara, Turkey

Gazi University Hospital; 🇹🇷 Ankara, Turkey

Ankara University Medical Faculty; 🇹🇷 Ankara, Turkey

Ankara Bilkent City Hospital; 🇹🇷 Ankara, Turkey

Bursa Yuksek lhtisas EAH Medikal Onkoloji Klinigi; 🇹🇷 Bursa, Turkey

Trakya University Medical Faculty; 🇹🇷 Edirne, Turkey

Istanbul University Istanbul Medical Faculty; 🇹🇷 Istanbul, Turkey

Istanbul Universitesi Cerrahpasa Tip Fakultesi Ic Hastaliklari Anabilim Dali Medikal Onkoloji Bd; 🇹🇷 Istanbul, Turkey

Bakirkoy Training and Research Hospital; 🇹🇷 Istanbul, Turkey

T C Saglik Bakanlıgi Goztepe Prof Dr Suleyman Yalcın Sehir Hastanesi; 🇹🇷 Istanbul, Turkey

Dokuz Eylul University Medical Faculty; 🇹🇷 Izmir, Turkey

Izmir Medical Point Hospital; 🇹🇷 Izmir, Turkey

Sakarya University Training and Research Hospital; 🇹🇷 Sakarya, Turkey

Medical Park Samsun Hastanesi; 🇹🇷 Samsun, Turkey

CNE Clinical Center of Oncology Hematology Transplantology and Palliative Care of the Cherkasy RC; 🇺🇦 Cherkasy, Ukraine

Municipal Non-profit enterprise 'Bukovinian clinical oncology center'; 🇺🇦 Chernivtsi, Ukraine

Ce 'Dnipropetrovsk Regional Clinical Hospital N.A. Mechnikov' of Dnipropetrovsk Rc; 🇺🇦 Dnipro, Ukraine

Municipal Institution 'Clinical Oncology Dispensary' Under Dnipropetrovsk Regional Council; 🇺🇦 Dnipro, Ukraine

Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4; 🇺🇦 Dnipro, Ukraine

Ivano-Frankivsk Regional Clinical Hospital; 🇺🇦 Ivano-Frankivsk, Ukraine

Communal Institution 'City hospital №7 of Kamianske' of Dnepropetrov'sk Regional Council; 🇺🇦 Kamianske, Ukraine

Municipal non-profit enterprise 'Regional Center of Oncology'; 🇺🇦 Khakhiv, Ukraine

Regional Medical Clinical Center for Urology and Nephrology named after V.I. Shapoval; 🇺🇦 Kharkiv, Ukraine

Kherson Regional Oncological Dispensary; 🇺🇦 Kherson, Ukraine

Nonprofit Organization National Cancer Institute; 🇺🇦 Kyiv, Ukraine

State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center; 🇺🇦 Kyiv, Ukraine

Kyiv Regional Oncological Dispensary; 🇺🇦 Kyiv, Ukraine

Communal Noncommercial Enterprise of Lviv Regional Council 'Lviv Regional Clinical Hospital'; 🇺🇦 Lviv, Ukraine

Podilskiy Regional Center of Oncology; 🇺🇦 Vinnitsa, Ukraine

Communal Institution 'Regional Oncology Dispensary' of Zhytomyr Region Council; 🇺🇦 Zhytomyr, Ukraine

Ysbyty Gwynedd; 🇬🇧 Bangor, United Kingdom

Belfast City Hospital; 🇬🇧 Belfast, United Kingdom

Brighton and Sussex University Hospitals NHS Trust; 🇬🇧 Brighton, United Kingdom

Bristol Haematology and Oncology Centre; 🇬🇧 Bristol, United Kingdom

Guy's Hospital; 🇬🇧 Great Maze Pond, United Kingdom

Prince Of Wales Hospital; 🇬🇧 Grimsby, United Kingdom

Marie Curie Research Wing - Mount Vernon Hospital; 🇬🇧 Hillingdon, United Kingdom

Raigmore Hospital; 🇬🇧 Inverness, United Kingdom

University College London Hospitals NHSFT; 🇬🇧 London, United Kingdom

Churchill Hospital; 🇬🇧 Oxford, United Kingdom

Royal Preston Hospital; 🇬🇧 Preston, United Kingdom

Royal Marsden Hospital; 🇬🇧 Sutton, United Kingdom

Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital; 🇬🇧 Truro, United Kingdom