A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
- Conditions
- Metastatic Castration-sensitive Prostate Cancer
- Interventions
- Registration Number
- NCT04497844
- Lead Sponsor
- Janssen Research & Development, LLC
- Brief Summary
The purpose of the study is to determine if the combination of niraparib with Abiraterone Acetate (AA) plus prednisone compared with AA plus prednisone in participants with deleterious germline or somatic Homologous Recombination Repair (HRR) gene-mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) provides superior efficacy in improving radiographic progression-free survival (rPFS).
- Detailed Description
Prostate cancer is a heterogenous disease and recent genomic analyses have highlighted specific germline and somatic mutations and alternative driver growth signaling pathways in patients with metastatic disease. Abiraterone acetate plus prednisone (AAP) is an established standard of care for the treatment of participants with mCSPC and is included in widely accepted clinical treatment guidelines. Niraparib in combination with AAP has been approved for the treatment of BRCA-mutated Metastatic Castration-Resistant Prostate Cancer (mCRPC). Niraparib is an investigational agent in the Metastatic Castration-Sensitive Prostate Cancer (mCSPC) population. Whether the addition of niraparib to the AAP standard of care may improve initial disease control and long-term outcomes compared with AAP alone in a biomarker selected mCSPC population is being evaluated on this trial. The study will consist of 4 phases; a Prescreening Phase for biomarker evaluation for eligibility only, a Screening Phase, a Treatment Phase, and a Follow-up Phase. Efficacy evaluations include the following: tumor measurements by computed tomography (CT), magnetic resonance imaging (MRI; abdomen, chest, and pelvis), Technetium-99m (99mTc) bone scans, serum prostate sensitive antigen (PSA) evaluations, and patient reported outcomes (PROs). Safety evaluations include incidence of adverse events and clinical laboratory parameters.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- Male
- Target Recruitment
- 696
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Niraparib with Abiraterone Acetate plus Prednisone (AAP) Niraparib Participants will receive the following in each 28-day treatment cycle: niraparib 200 milligrams (mg), abiraterone acetate (AA) 1000 mg plus prednisone 5 mg once daily. Niraparib with Abiraterone Acetate plus Prednisone (AAP) Prednisone Participants will receive the following in each 28-day treatment cycle: niraparib 200 milligrams (mg), abiraterone acetate (AA) 1000 mg plus prednisone 5 mg once daily. Niraparib with Abiraterone Acetate plus Prednisone (AAP) Abiraterone acetate (AA) Participants will receive the following in each 28-day treatment cycle: niraparib 200 milligrams (mg), abiraterone acetate (AA) 1000 mg plus prednisone 5 mg once daily. AA plus Prednisone (AAP) Abiraterone acetate (AA) Participants will receive the following in each 28-day treatment cycle: matching placebo for Niraparib along with AA 1000 mg plus prednisone 5 mg once daily. AA plus Prednisone (AAP) Prednisone Participants will receive the following in each 28-day treatment cycle: matching placebo for Niraparib along with AA 1000 mg plus prednisone 5 mg once daily. AA plus Prednisone (AAP) Placebo for Niraparib Participants will receive the following in each 28-day treatment cycle: matching placebo for Niraparib along with AA 1000 mg plus prednisone 5 mg once daily.
- Primary Outcome Measures
Name Time Method Radiographic Progression-free Survival (rPFS) Up to 47 months rPFS is defined as time from randomization date to date of radiographic progression or death, whichever occurs first. Radiographic progression will be evaluated by Prostate Cancer Working Group 3 (PCWG3) criteria and Response Evaluation Criteria in Solid Tumors (RECIST 1.1).
- Secondary Outcome Measures
Name Time Method Overall Survival (OS) Up to 78 months OS is defined as the time from date of randomization to date of death from any cause.
Time to Symptomatic Progression Up to 47 months Time to symptomatic progression is defined as time from the date of randomization to the date of any of the following (whichever occurs first): a) the use of external beam radiation therapy for skeletal or pelvic symptoms; b) the need for tumor-related orthopedic surgical intervention; c) other cancer-related procedures; d) cancer-related morbid events; e) initiation of a new systemic anti-cancer therapy because of cancer symptoms.
Time to Subsequent Therapy Up to 47 months Time to Subsequent Therapy is defined as the time from date of randomization to the date of initiation of subsequent therapy for prostate cancer.
Number of Participants with Adverse Events as a Measure of Safety and Tolerability Up to 78 months An adverse event (AE) is any untoward medical occurrence in a clinical study participant administered a medicinal (investigational or non investigational) product. AE does not necessarily have a causal relationship with intervention.
Trial Locations
- Locations (385)
CHU UCL Namur - Site Sainte Elisabeth
🇧🇪Namur, Belgium
Clinique St Pierre
🇧🇪Ottignies, Belgium
Instituto do Cancer Arnaldo Vieira de Carvalho
🇧🇷São Paulo, Brazil
Núcleo de Pesquisa São Camilo
🇧🇷São Paulo, Brazil
Centro Oncológico do Triângulo
🇧🇷Uberlândia, Brazil
MHAT Deva Maria
🇧🇬Burgas, Bulgaria
UMHAT 'Dr. Georgi Stranski', EAD
🇧🇬Pleven, Bulgaria
Complex Oncology Center - Plovdiv EOOD
🇧🇬Plovdiv, Bulgaria
Hospital Pulau Pinang
🇲🇾George Town, Malaysia
Hospital Sultan Ismail
🇲🇾Johor Bahru, Malaysia
Hospital Kuala Lumpur
🇲🇾Kuala Lumpur, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Malaysia
Corporacio Sanitari Parc Tauli
🇪🇸Sabadell, Spain
Hosp. Univ. Marques de Valdecilla
🇪🇸Santander, Spain
Hosp. Virgen Del Rocio
🇪🇸Sevilla, Spain
Hosp. Clinico Univ. de Valencia
🇪🇸Valencia, Spain
Salgrenska University hospital
🇸🇪Göteborg, Sweden
Urologiska Mottagningen
🇸🇪Malmö, Sweden
Sodersjukhuset
🇸🇪Stockholm, Sweden
Karolinska Universitetssjukhuset Solna
🇸🇪Stockholm, Sweden
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung City, Taiwan
Kaohsiung Medical University Chung Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
Tungs' Taichung MetroHarbor Hospital
🇨🇳Taichung, Taiwan
National Taiwan University Hospital.
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Chang-Gung Memorial Hospital, LinKou Branch
🇨🇳Taoyuan, Taiwan
King Chulalongkorn Memorial Hospital
🇹🇭Bangkok, Thailand
Ramathibodi Hospital
🇹🇭Bangkok, Thailand
Siriraj Hospital
🇹🇭Bangkok, Thailand
Adana Baskent Yuregir Hospital
🇹🇷Adana, Turkey
Guy s Hospital
🇬🇧Great Maze Pond, United Kingdom
Puerto Rico Medical Research Center
🇵🇷Hato Rey, Puerto Rico
Altai Regional Oncology Dispensary
🇷🇺Barnaul, Russian Federation
Chelyabinsk Regional Clinical Center Of Oncology And Nuclear Medicine
🇷🇺Chelyabinsk, Russian Federation
Ivanovo Regional Oncology Dispensary
🇷🇺Ivanovo, Russian Federation
Moscow City Clinical Hospital # 62
🇷🇺Moscow, Russian Federation
Hertzen Oncology Research Institute
🇷🇺Moscow, Russian Federation
Privolzhsky District Medical Centre
🇷🇺Nizhny Novgorod, Russian Federation
Clinical Oncology Dispensary
🇷🇺Omsk, Russian Federation
LLC Novaya Clinica
🇷🇺Pyatigorsk, Russian Federation
Pyatigorsk Interdistrict Oncology Dispensary
🇷🇺Pyatigorsk, Russian Federation
Private Medical Institution Euromedservice
🇷🇺Saint Petersburg, Russian Federation
Leningrad Regional Oncology Dispensary
🇷🇺Saint-Petersburg, Russian Federation
Republican Oncology Dispensary
🇷🇺Saransk, Russian Federation
Tomsk Cancer Research Institute
🇷🇺Tomsk, Russian Federation
Multifunctional clinical medical center 'Medical city'
🇷🇺Tyumen, Russian Federation
Bashkir State Medical University
🇷🇺Ufa, Russian Federation
CancerCare Rondebosch
🇿🇦Cape Town, South Africa
Steve Biko Academic Hospital
🇿🇦Pretoria, South Africa
East Rand Urology Research Unit
🇿🇦Vosloorus, South Africa
Hosp Univ A Coruna
🇪🇸A Coruna, Spain
Hosp. de La Santa Creu I Sant Pau
🇪🇸Barcelona, Spain
Hosp Clinic de Barcelona
🇪🇸Barcelona, Spain
Hosp. Gral. Univ. de Castellon
🇪🇸Castellon, Spain
Institut Català D'Oncologia Girona
🇪🇸Girona, Spain
Hosp. de Jerez de La Frontera
🇪🇸Jerez de la Frontera, Spain
Hosp. Univ. de La Princesa
🇪🇸Madrid, Spain
Hosp. Univ. Ramon Y Cajal
🇪🇸Madrid, Spain
Hosp. Univ. 12 de Octubre
🇪🇸Madrid, Spain
Hosp. Univ. La Paz
🇪🇸Madrid, Spain
Hosp. Univ. Hm Monteprincipe
🇪🇸Madrid, Spain
Hosp Virgen de La Victoria
🇪🇸Málaga, Spain
The First Affiliated Hospital of Ningbo University
🇨🇳Ningbo, China
Uls Almada Seixal - Hosp. Garcia de Orta
🇵🇹Almada, Portugal
Kyiv Regional Oncological Dispensary
🇺🇦Kyiv, Ukraine
Urology Centers Of Alabama
🇺🇸Homewood, Alabama, United States
Mayo Clinic Arizona
🇺🇸Phoenix, Arizona, United States
Urological Associates of Southern Arizona, P.C.
🇺🇸Tucson, Arizona, United States
Greater Los Angeles VA Healthcare System
🇺🇸Los Angeles, California, United States
University of California Irvine Medical Center Chao Family Comprehensive Cancer Center
🇺🇸Orange, California, United States
San Bernardino Urological Associates
🇺🇸San Bernardino, California, United States
University of San Francisco California
🇺🇸San Francisco, California, United States
Rocky Mountain Cancer Centers
🇺🇸Colorado Springs, Colorado, United States
AdventHealth Medical Group Urology of Denver
🇺🇸Denver, Colorado, United States
Colorado Clinical Research
🇺🇸Lakewood, Colorado, United States
Eastern Connecticut Hematology & Oncology Assoc.
🇺🇸Norwich, Connecticut, United States
Advanced Urology Institute
🇺🇸Daytona Beach, Florida, United States
Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center
🇺🇸Fort Lauderdale, Florida, United States
University of Florida Health Jacksonville
🇺🇸Jacksonville, Florida, United States
Cancer Specialists of North Florida
🇺🇸Jacksonville, Florida, United States
Urology of Indiana
🇺🇸Greenwood, Indiana, United States
First Urology
🇺🇸Jeffersonville, Indiana, United States
Ochsner Clinic Foundation
🇺🇸New Orleans, Louisiana, United States
Baltimore VA Medical Center
🇺🇸Baltimore, Maryland, United States
Maryland Oncology Hematology, PA
🇺🇸Columbia, Maryland, United States
Chesapeake Urology Associates
🇺🇸Towson, Maryland, United States
Michigan Institute of Urology
🇺🇸Troy, Michigan, United States
Mosaic Life Care
🇺🇸Saint Joseph, Missouri, United States
St. Louis VA Medical Center
🇺🇸Saint Louis, Missouri, United States
GU Research Network
🇺🇸Omaha, Nebraska, United States
New York Oncology Hematology
🇺🇸Albany, New York, United States
Montefiore Medical Center
🇺🇸Bronx, New York, United States
Manhattan VAMC
🇺🇸New York, New York, United States
Mount Sinai
🇺🇸New York, New York, United States
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
Associated Medical Professionals
🇺🇸Syracuse, New York, United States
Durham VAMC
🇺🇸Durham, North Carolina, United States
Stephenson Cancer Center
🇺🇸Oklahoma City, Oklahoma, United States
VA Portland Health Care System
🇺🇸Portland, Oregon, United States
Oregon Oncology Specialists
🇺🇸Salem, Oregon, United States
Keystone Urology Specialists
🇺🇸Lancaster, Pennsylvania, United States
Philadelphia VA Medical Center
🇺🇸Philadelphia, Pennsylvania, United States
University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center (UPMC)
🇺🇸Pittsburgh, Pennsylvania, United States
Ralph H. Johnson Veterans Affairs Medical Center
🇺🇸Charleston, South Carolina, United States
Prisma Health
🇺🇸Seneca, South Carolina, United States
Urology Associates
🇺🇸Nashville, Tennessee, United States
Texas Oncology-Austin
🇺🇸Austin, Texas, United States
Texas Oncology - Northeast
🇺🇸Tyler, Texas, United States
Houston Metro Urology
🇺🇸Houston, Texas, United States
Texas Oncology P A
🇺🇸New Braunfels, Texas, United States
University of Utah Huntsman Cancer Institute
🇺🇸Salt Lake City, Utah, United States
Virginia Oncology Associates
🇺🇸Norfolk, Virginia, United States
Virginia Commonwealth University - Massey Cancer Center
🇺🇸Richmond, Virginia, United States
VA Puget Sound Healthcare System
🇺🇸Seattle, Washington, United States
Seattle Cancer Care Alliance
🇺🇸Seattle, Washington, United States
MultiCare Health System
🇺🇸Tacoma, Washington, United States
Sociedade Beneficente de Senhoras Hospital Sirio Libanes
🇦🇷Buenos Aires, Argentina
Centro Oncológico Korben
🇦🇷Buenos Aires, Argentina
Hospital Militar Cosme Argerich
🇦🇷C.a.b.a., Argentina
CINME Centro de Investigaciones Metabolicas
🇦🇷Caba, Argentina
CIPREC Arenales
🇦🇷Caba, Argentina
Centro de Urologia (CDU)
🇦🇷Ciudad Automoma Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
🇦🇷Ciudad Autonoma de, Argentina
Clinica Adventista Belgrano
🇦🇷Ciudad De Buenos Aires, Argentina
Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica
🇦🇷Cordoba, Argentina
Centro Urologico Profesor Bengio
🇦🇷Cordoba, Argentina
Instituto Médico de Río Cuarto
🇦🇷Cordoba, Argentina
Hospital Privado de Cordoba
🇦🇷Cordoba, Argentina
Hospital Privado de Comunidad
🇦🇷Mar Del Plata, Argentina
Centro de Investigacion Pergamino SA
🇦🇷Pergamino, Argentina
ARS Médica
🇦🇷San Salvador De Jujuy, Argentina
Sunshine Coast University Hospital
🇦🇺Birtinya, Australia
St Vincent s Hospital Sydney
🇦🇺Darlinghurst, Australia
Cancer Care Services Clinical Research Unit
🇦🇺Herston, Australia
Royal Hobart Hospital
🇦🇺Hobart, Australia
Icon Cancer Centre Kurralta Park
🇦🇺Kurralta Park, Australia
Liverpool Hospital
🇦🇺Liverpool, Australia
Peter MacCallum Cancer Centre
🇦🇺Melbourne, Australia
Fiona Stanley Hospital
🇦🇺Murdoch, Australia
Macquarie University Hospital
🇦🇺North Ryde, Australia
ICON Cancer Care
🇦🇺South Brisbane, Australia
St John of God Subiaco Hospital
🇦🇺Subiaco, Australia
Bobruisk Interregional Oncology Dispensary
🇧🇾Bobruisk, Belarus
Brest Regional Oncology Dispensary
🇧🇾Brest, Belarus
Gomel Regional Clinical Oncology Dispensary
🇧🇾Gomel, Belarus
Grodno University Hospital
🇧🇾Grodno, Belarus
N N Alexandrov National Cancer Centre of Belarus
🇧🇾Lesnoy, Belarus
Minsk city Clinical Oncological Dispensary
🇧🇾Minsk, Belarus
Mogilev Regional Oncology Dispensary
🇧🇾Mogilev, Belarus
Vitebsk Regional Clinical Oncology Dispensary
🇧🇾Vitebsk, Belarus
ZNA Middelheim
🇧🇪Antwerp, Belgium
Grand Hopital De Charleroi Site Les Viviers
🇧🇪Charleroi, Belgium
Jolimont
🇧🇪Haine-St-Paul, Belgium
CHC MontLegia
🇧🇪Liege, Belgium
Rambam Medical Center
🇮🇱Haifa, Israel
Algemeen Ziekenhuis Delta
🇧🇪Roeselare, Belgium
GZA Ziekenhuizen
🇧🇪Wilrijk, Belgium
Fundacao Pio XII
🇧🇷Barretos, Brazil
Cetus Oncologia
🇧🇷Belo Horizonte, Brazil
PERSONAL Oncologia de Precisao e Personalizada
🇧🇷Belo Horizonte, Brazil
CIONC Centro Integrado de Oncologia de Curitiba
🇧🇷Curitiba, Brazil
Centro de Pesquisa e Ensino em Oncologia de Santa Catarina CEPEN
🇧🇷Florianopolis, Brazil
Pronutrir
🇧🇷Fortaleza, Brazil
Associacao de Combate ao Cancer em Goias - Hospital de Cancer Araujo Jorge
🇧🇷Goiania, Brazil
Fundação São Francisco Xavier
🇧🇷Ipatinga, Brazil
Instituto Joinvilense de Hematologia e Oncologia Ltda Centro de Hematologia e Oncologia
🇧🇷Joinville, Brazil
Liga Norte Riograndense Contra O Cancer
🇧🇷Natal, Brazil
UPCO Unidade de Pesquisa Clinica em Oncologia
🇧🇷Pelotas, Brazil
Irmandade Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, Brazil
Hospital Ernesto Dornelles
🇧🇷Porto Alegre, Brazil
MultiHemo Servicos Medicos S.A
🇧🇷Recife, Brazil
Ministerio da Saude Instituto Nacional do Cancer
🇧🇷Rio de Janeiro, Brazil
Universidade do Estado do Rio de Janeiro - UERJ
🇧🇷Rio de Janeiro, Brazil
Oncoclinicas Rio de Janeiro S A
🇧🇷Rio de Janeiro, Brazil
Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)
🇧🇷Rio de Janeiro, Brazil
Nucleo de Oncologia da Bahia
🇧🇷Salvador, Brazil
Hospital Sao Rafael
🇧🇷Salvador, Brazil
Fundacao do ABC Centro Universitario FMABC
🇧🇷Santo Andre, Brazil
Irmandade Santa Casa de Misericordia de Sao Paulo
🇧🇷Sao Paulo, Brazil
Instituto de Ensino e Pesquisa São Lucas
🇧🇷Sao Paulo, Brazil
Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo
🇧🇷Sao Paulo, Brazil
Real e Benemerita Associacao Portuguesa de Beneficencia
🇧🇷Sao Paulo, Brazil
Hospital Alemao Oswaldo Cruz
🇧🇷Sao Paulo, Brazil
Instituto de Assistencia Medica ao Servidor Publico Estadual IAMSPE
🇧🇷Sao Paulo, Brazil
IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado
🇧🇷Sorocaba, Brazil
Multifunctional Hospital for Active Treatment for Women Health Nadezhda
🇧🇬Sofia, Bulgaria
Specialized Hospital for Active Treatment in Oncology
🇧🇬Sofia, Bulgaria
UMHAT Sofia Med
🇧🇬Sofia, Bulgaria
Comprehensive Cancer Center
🇧🇬Vratsa, Bulgaria
Prostate Cancer Centre
🇨🇦Calgary, Alberta, Canada
Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada
British Columbia Cancer Agency(BCCA)-Sindi Ahluwalia Hawkins Centre for the Southern Interior(CSI)
🇨🇦Kelowna, British Columbia, Canada
British Columbia Cancer Agency BCCA Vancouver Centre
🇨🇦Vancouver, British Columbia, Canada
British Columbia Cancer Agency Vancouver Island Centre
🇨🇦Victoria, British Columbia, Canada
McMaster Institute of Urology
🇨🇦Hamilton, Ontario, Canada
Kingston Health Sciences Centre, Kingston General Health Research Institute
🇨🇦Kingston, Ontario, Canada
Sunnybrook Health Sciences Center
🇨🇦Toronto, Ontario, Canada
Princess Margaret Cancer Centre University Health Network
🇨🇦Toronto, Ontario, Canada
Centre Hospitalier de l'Universite de Montreal
🇨🇦Montreal, Quebec, Canada
McGill University - Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
Cancer Hospital Chinese Academy of Medical Sciences
🇨🇳Beijing, China
Peking University First Hospital
🇨🇳Beijing, China
Beijing Friendship Hospital Capital Medical University
🇨🇳Beijing, China
Beijing Cancer Hospital
🇨🇳Beijing, China
Beijing University Third Hospital
🇨🇳Beijing, China
Beijing Hospital
🇨🇳Beijing, China
West China Hospital of Sichuan University
🇨🇳Chengdu, China
Sichuan Provincial Peoples Hospital
🇨🇳Chengdu, China
Western Theater General Hospital of the Chinese People's Liberation Army
🇨🇳Chengdu, China
Chongqing University Cancer Hospital
🇨🇳Chongqing, China
Southwest Hospital, The Third Military Medical University
🇨🇳Chongqing, China
Sun Yat Sen University Cancer Center
🇨🇳GuangZhou, China
Guangzhou First Municipal People's Hospital
🇨🇳Guangzhou, China
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
🇨🇳Guangzhou, China
Zhejiang Provincial People's Hospital
🇨🇳Hangzhou, China
The First Affiliated Hospital of NanChang University
🇨🇳Nanchang, China
Jiangsu Province Cancer Hospital
🇨🇳Nanjing, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, China
Huashan Hospital Fudan University
🇨🇳Shanghai, China
Renji Hospital Affiliated to Medical College of Shanghai Jiaotong University
🇨🇳Shanghai, China
The Fifth People's Hospital of Shanghai, Fudan University
🇨🇳Shanghai, China
Huadong Hospital Affiliated to Fudan University
🇨🇳Shanghai, China
Shengjing Hospital Of China Medical University
🇨🇳Shenyang, China
Second Affiliated Hospital of Soochow University
🇨🇳SuZhou, China
The First Affliated Hospital of Soochow University
🇨🇳Suzhou, China
The First Affiliated Hospital of Wenzhou Medical University
🇨🇳Wenzhou, China
TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology
🇨🇳Wuhan, China
The First Affiliated Hospital of Xian Jiaotong University
🇨🇳XI An, China
Fakultni nemocnice u sv. Anny v Brne
🇨🇿Brno, Czechia
FN Hradec Kralove, Urologicka klinika
🇨🇿Hradec Kralove, Czechia
Krajská nemocnice Liberec
🇨🇿Liberec, Czechia
Uromedical Center s.r.o.
🇨🇿Olomouc, Czechia
Urologicka klinika 1 LF UK a VFN
🇨🇿Praha 2, Czechia
Aalborg University Hospital
🇩🇰Aalborg, Denmark
Copenhagen University Hospital
🇩🇰Copenhagen, Denmark
Herlev Hospital
🇩🇰Herlev, Denmark
Næstved Hospital
🇩🇰Naestved, Denmark
Odense Universitetshospital
🇩🇰Odense, Denmark
Vejle Hospital
🇩🇰Vejle, Denmark
Institut de Cancerologie de l Ouest ICO
🇫🇷Angers Cedex 9, France
Institut Sainte Catherine
🇫🇷Avignon Cedex 9, France
CHRU De Besancon
🇫🇷Besancon, France
Institut Bergonie
🇫🇷Bordeaux, France
Centre Jean Perrin
🇫🇷Clermont Ferrand, France
Centre Georges Francois Leclerc
🇫🇷Dijon, France
Centre Oscar Lambret
🇫🇷Lille, France
Centre Leon Berard
🇫🇷Lyon, France
Hopital Prive Jean Mermoz
🇫🇷Lyon, France
Institut Regional du Cancer de Montpellier Val d'Aurelle
🇫🇷Montpellier, France
Polyclinique de Gentilly
🇫🇷Nancy, France
CHU De Poitiers
🇫🇷Poitiers Cedex, France
Centre Hopitalier Inter-Communal De Cornouaille
🇫🇷Quimper, France
HIA Begin
🇫🇷Saint Mande, France
Institut de Cancérologie de Loire
🇫🇷Saint-Priest-en-Jarez, France
Clinique Sainte Anne
🇫🇷Strasbourg, France
Hopital Foch
🇫🇷Suresnes, France
CHRU de Tours
🇫🇷Tours, France
Städtisches Klinikum Braunschweig gGmbH - Standort Salzdahlumer
🇩🇪Braunschweig, Germany
Universitätsklinik Carl Gustav Carus, Med. Klinik u. Poliklinik I
🇩🇪Dresden, Germany
Urologicum Duisburg
🇩🇪Duisburg, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Universitaetsklinikum Koelnt
🇩🇪Koeln, Germany
Universitaetsklinikum Muenster
🇩🇪Muenster, Germany
Klinikum rechts der Isar - III. Med. Klinik und Poliklinik
🇩🇪München, Germany
Studienpraxis Urologie Drs. Feyerabend
🇩🇪Nuertingen, Germany
Jahn Ferenc Del-pesti Korhaz es Rendelointezet
🇭🇺Budapest, Hungary
Debreceni Egyetem
🇭🇺Debrecen, Hungary
Petz Aladar Megyei Oktato Korhaz
🇭🇺Gyor, Hungary
Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz
🇭🇺Gyula, Hungary
Borsod Abauj Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktato Korhaz
🇭🇺Miskolc, Hungary
Szegedi Tudomanyegyetem
🇭🇺Szeged, Hungary
Szent Borbala Hospital Tatabanya
🇭🇺Tatabanya, Hungary
Haemek Medical Center - Afula
🇮🇱Afula, Israel
Soroka Hospital
🇮🇱Beer-Sheva, Israel
Hadassah Hospital
🇮🇱Jerusalem, Israel
Rabin Medical Center, Beilinson Hospital
🇮🇱Petach Tikvah, Israel
Sheba Medical Center Tel Hashomer
🇮🇱Ramat Gan, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel-Aviv, Israel
Ospedale S. Donato - Asl 8 Arezzo
🇮🇹Arezzo, Italy
Divisione di Oncologia - Istituto per la ricerca e cura del cancro
🇮🇹Candiolo, Italy
Istituti Ospitalieri di Cremona, AO di Cremona
🇮🇹Cremona, Italy
Azienda Ospedaliera ''Vito Fazzi''
🇮🇹Lecce, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
🇮🇹Meldola, Italy
Ospedale San Raffaele
🇮🇹Milano, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
🇮🇹Milano, Italy
European Institute of Oncology
🇮🇹Milano, Italy
Fondazione G Pascale Istituto Nazionale Tumori IRCCS
🇮🇹Napoli, Italy
Aou San Luigi Gonzaga
🇮🇹Orbassano, Italy
Istituto Oncologico Veneto Iov Irccs Padova
🇮🇹Padova, Italy
Azienda Ospedaliero Universitaria Pisana
🇮🇹Pisa, Italy
ASL Napoli 2 Nord-SM delle Grazie Hospital
🇮🇹Pozzuoli, Italy
Casa Sollievo Della Sofferenza IRCCS
🇮🇹San Giovanni Rotondo, Italy
Ospedale S. Chiara
🇮🇹Trento, Italy
Ospedale San Bortolo
🇮🇹Vicenza, Italy
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
Kyungpook National University Chilgok Hospital
🇰🇷Daegu, Korea, Republic of
Keimyung University Dongsan Hospital
🇰🇷Daegu, Korea, Republic of
Chungnam National University Hospital
🇰🇷Daejeon, Korea, Republic of
Chonnam National University Hospital
🇰🇷Gwangju, Korea, Republic of
National Cancer Center
🇰🇷Gyeonggi-do, Korea, Republic of
Ajou University Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Gangnam Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea Seoul St Mary s Hospital
🇰🇷Seoul, Korea, Republic of
Sarawak General Hospital
🇲🇾Kuching, Malaysia
Institut Kanser Negara Clinical Research Center
🇲🇾Putrajaya, Malaysia
Centro de Investigación Clínica Gramel S.C.
🇲🇽Ciudad de Mexico, Mexico
Consultorio de Especialidad en Urologia Privado
🇲🇽Durango, Mexico
Consultorio Privado
🇲🇽Zapopan, Mexico
Avix Investigacion Clinica S C
🇲🇽Monterrey, Mexico
i Can Oncology Center
🇲🇽Monterrey, Mexico
Oncologia Integral Satelite
🇲🇽Naucalpan, Mexico
Consultorio de Oncología Médica
🇲🇽Oaxaca, Mexico
Reinier de Graaf Gasthuis
🇳🇱Delft, Netherlands
Tergooiziekenhuizen
🇳🇱Hilversum, Netherlands
Canisius-Wilhelminaziekenhuis
🇳🇱Nijmegen, Netherlands
Elisabeth-TweeSteden Ziekenhuis
🇳🇱Tilburg, Netherlands
Auckland City Hospital
🇳🇿Auckland, New Zealand
Canterbury Urology Research Trust
🇳🇿Christchurch, New Zealand
Dunedin Hospital
🇳🇿Dunedin Central, New Zealand
Tauranga Hospital
🇳🇿Tauranga, New Zealand
IN VIVO Sp. z o.o
🇵🇱Bydgoszcz, Poland
Szpital Uniwersytecki NR 1 IM Dr Antoniego Jurasza
🇵🇱Bydgoszcz, Poland
Centrum Onkologii im Prof F Lukaszczyka
🇵🇱Bydgoszcz, Poland
Szpitale Pomorskie Sp z o o
🇵🇱Gdynia, Poland
Przychodnia Lekarska KOMED Roman Karaszewski
🇵🇱Konin, Poland
Klinika MedTrials
🇵🇱Krakow, Poland
Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi
🇵🇱Lodz, Poland
Medisport
🇵🇱Lublin, Poland
Urologica Praktyka Lekarska Adam Marcheluk
🇵🇱Siedlce, Poland
Szpital Grochowski Im Dr Med Rafala Masztaka Sp Z O O
🇵🇱Warszawa, Poland
Specjalistyczna przychodnia lekarska POLIMED
🇵🇱Wroclaw, Poland
Instituto Português de Oncologia Francisco Gentil - Centro Regional de Oncologia de Coimbra, S.A.
🇵🇹Coimbra, Portugal
Fund. Champalimaud
🇵🇹Lisboa, Portugal
Uls Santa Maria - Hosp. Santa Maria
🇵🇹Lisboa, Portugal
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital
🇹🇷Ankara, Turkey
Memorial Ankara Hastanesi
🇹🇷Ankara, Turkey
Gazi University Hospital
🇹🇷Ankara, Turkey
Ankara University Medical Faculty
🇹🇷Ankara, Turkey
Ankara Bilkent City Hospital
🇹🇷Ankara, Turkey
Bursa Yuksek lhtisas EAH Medikal Onkoloji Klinigi
🇹🇷Bursa, Turkey
Trakya University Medical Faculty
🇹🇷Edirne, Turkey
Istanbul University Istanbul Medical Faculty
🇹🇷Istanbul, Turkey
Istanbul Universitesi Cerrahpasa Tip Fakultesi Ic Hastaliklari Anabilim Dali Medikal Onkoloji Bd
🇹🇷Istanbul, Turkey
Bakirkoy Training and Research Hospital
🇹🇷Istanbul, Turkey
T C Saglik Bakanlıgi Goztepe Prof Dr Suleyman Yalcın Sehir Hastanesi
🇹🇷Istanbul, Turkey
Dokuz Eylul University Medical Faculty
🇹🇷Izmir, Turkey
Izmir Medical Point Hospital
🇹🇷Izmir, Turkey
Sakarya University Training and Research Hospital
🇹🇷Sakarya, Turkey
Medical Park Samsun Hastanesi
🇹🇷Samsun, Turkey
CNE Clinical Center of Oncology Hematology Transplantology and Palliative Care of the Cherkasy RC
🇺🇦Cherkasy, Ukraine
Municipal Non-profit enterprise 'Bukovinian clinical oncology center'
🇺🇦Chernivtsi, Ukraine
Ce 'Dnipropetrovsk Regional Clinical Hospital N.A. Mechnikov' of Dnipropetrovsk Rc
🇺🇦Dnipro, Ukraine
Municipal Institution 'Clinical Oncology Dispensary' Under Dnipropetrovsk Regional Council
🇺🇦Dnipro, Ukraine
Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4
🇺🇦Dnipro, Ukraine
Ivano-Frankivsk Regional Clinical Hospital
🇺🇦Ivano-Frankivsk, Ukraine
Communal Institution 'City hospital №7 of Kamianske' of Dnepropetrov'sk Regional Council
🇺🇦Kamianske, Ukraine
Municipal non-profit enterprise 'Regional Center of Oncology'
🇺🇦Khakhiv, Ukraine
Regional Medical Clinical Center for Urology and Nephrology named after V.I. Shapoval
🇺🇦Kharkiv, Ukraine
Kherson Regional Oncological Dispensary
🇺🇦Kherson, Ukraine
Nonprofit Organization National Cancer Institute
🇺🇦Kyiv, Ukraine
State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center
🇺🇦Kyiv, Ukraine
Communal Noncommercial Enterprise of Lviv Regional Council 'Lviv Regional Clinical Hospital'
🇺🇦Lviv, Ukraine
Podilskiy Regional Center of Oncology
🇺🇦Vinnitsa, Ukraine
Communal Institution 'Regional Oncology Dispensary' of Zhytomyr Region Council
🇺🇦Zhytomyr, Ukraine
Ysbyty Gwynedd
🇬🇧Bangor, United Kingdom
Belfast City Hospital
🇬🇧Belfast, United Kingdom
Brighton and Sussex University Hospitals NHS Trust
🇬🇧Brighton, United Kingdom
Bristol Haematology and Oncology Centre
🇬🇧Bristol, United Kingdom
Prince Of Wales Hospital
🇬🇧Grimsby, United Kingdom
Marie Curie Research Wing - Mount Vernon Hospital
🇬🇧Hillingdon, United Kingdom
Raigmore Hospital
🇬🇧Inverness, United Kingdom
University College London Hospitals NHSFT
🇬🇧London, United Kingdom
Churchill Hospital
🇬🇧Oxford, United Kingdom
Royal Preston Hospital
🇬🇧Preston, United Kingdom
Royal Marsden Hospital
🇬🇧Sutton, United Kingdom
Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital
🇬🇧Truro, United Kingdom