Examination of Cardiovascular Function/ Cardio Respiratory Interaction on Spontaneous Breathing Trials in Patients in the Prolonged Weaning

• Conditions: Cardiovascular Disease
• Interventions: Other: Spontaneous breathing trial

• Registration Number: NCT02569385
• Lead Sponsor: RWTH Aachen University

Brief Summary

The aim of the present study is to determine the cardiovascular function/ cardio respiratory interaction on spontaneous breathing trials in patients with prolonged weaning.

Detailed Description

Not available

Study Timeline

• Status Verified: 2015-08
• Study Start: 2015-08
• Study First Submitted: 2015-09-23
• Study First Submitted QC: 2015-10-02
• Last Update Submitted: 2015-10-02
• Study First Posted: 2015-10-06
• Last Update Posted: 2015-10-06
• Primary Completion: 2016-08
• Study Completion: 2016-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• legal Age (≥18 years)

• written informed consent Prior to study participation

• patient in prolonged weaning with NYHA I-II and an actual positive Ventilator Screening test:

  1. PaO2 ≥ 60 mmHg at FiO2 ≤ 0.4
  2. PEEP ≤ 8 cmH2O
  3. Glasgow Coma Scale > 13
  4. Temp. < 38°C
  5. Hb > 80-100 g/L
  6. less requirement on catecholamines (<0.1µg/kg/min)

• and on these patients are already performed a spontaneous breathing trial with following result:

  1. abortion this spontaneous breathing trial < 30min, but possible > 10min
  2. reason for an abortion was NOT hypercapnia

Exclusion Criteria

• weaning patients are assigned on Group 1-2
• patient with heart failure (NYHA III-IV) and/ or other cardiac comorbidity
• acute NSTEMI (non-ST-segment elevation myocardial infarction)
• pregnancy and breast-feeding

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
spontaneous breathing trials	Spontaneous breathing trial	spontaneous breathing trials in patients with prolonged weaning

Primary Outcome Measures

Name	Time	Method
Baseline measurement (Modus "CPAP-PS") in patient with prolonged weaning	12 months	under pressure support Ventilation are determined some measurement (e.g. breathing rate)

Secondary Outcome Measures

Name	Time	Method
Intervention measurement in patient with prolonged weaning	12 months	20 min breathing without mechanical ventilation

Trial Locations

Locations (1)

University Hospital RWTH Aachen, Department of Medical Clinic I; 🇩🇪 Aachen, 52074, Germany