Evidence and functions of surfactant-associated proteins and trefoil factor family (TFF) peptides in the synovial fluid, synovial membrane and cartilage tissue in children and adolescents with inflammatory joint diseases

Recruiting

Conditions: -Patients with any subtype of a JIA-Patients with infectious arthritis (Lyme arthritis)-Patients with septic arthritis-Patients with surgical synovectomy (JIA)-Non-infectious, deceased premature babies and newborns or deceased children and adolescents (autopsy material)
M08
Juvenile arthritis

Registration Number: DRKS00006057

Lead Sponsor: Dekanat der MLU Halle-Wittenberg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 135

Inclusion Criteria

Gender: Both, male and female
Minimum age: 1 day
Maximum age: 16 years

Additional Inclusion Criteria
1. Confirmed JIA (according to ILAR 1997)
2. Age = 1 day up to = 16 years for patients with JIA and joint infections
3. Age for autopsy cases (non-JIA): premature babies up to 16 years of age
4. In the case of JIA and non-synovectomy cases”: New manifestation of JIA and/or prior to use of immunomodulation (corticoids, MTX, other basic medications, biologicals)
5. Collection of a blood sample, puncture of the joint, arthroscopic synovectomies, open synovectomies or chondrectomies for a medical indication (e.g. JIA or joint infection)
6. Infections of joints before antibiotic treatment
7. Authorised autopsies for deceased children and adolescents

Exclusion Criteria

1. Patients with JIA that belong to none or 2 subtypes of JIA
2. Any infection in the autopsy group
3. Any infection in the JIA group
4. Any infection in the synovectomy group
5. Lack of medical indication to collect blood samples, arthrocenteses, synovectomies, chondrectomies or procedures on the joint in general
6. Patients who have already commenced immunosuppression or immunomodulation in the JIA group (non-synovectomies)
7. Procedures on the jaw joint
8. Suspected shaken baby syndrome in the autopsy groups
9. Lack of written consent forms of the parents and/or patients to any medically indicated joint procedures or to collect blood samples
10. Lack of written informed consent forms of the parents/guardians in the cases of clinical post mortem examinations (autopsy cases)
11. Lack of written consent of the public prosecution office in exceptional cases involving court-ordered post mortem examinations

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Qualitative and quantitative determination of surface-active substances in the case of JIA in comparison to healthy” joints and other joint diseases (SP-A to -H)<br>2. Qualitative and quantitative determination of trefoil factor family peptides TFF 1-3 in various joint diseases<br>3. Correlation of the evidence of the above-named substances with the age, tissue type or compartment (cartilage, synovial membrane, synovial fluid, blood) as well as the type of joint disease and disease activity <br>

Secondary Outcome Measures

Name	Time	Method
1. Deeper understanding and generation of new knowledge with respect to the pathomechanism of joint diseases in children, in particular also the role inherent immunity plays in this<br>2. Identify possible new targets for anti-rheumatic treatment<br>