Physiological Effects of High-Flow Tracheal Oxygen Via An Modified Interface

Completed

• Conditions: Tracheostomy
• Interventions: Procedure: The modified HFT

• Registration Number: NCT03244761
• Lead Sponsor: Capital Medical University

Brief Summary

Tracheostomy is often performed in patients after or anticipated prolonged mechanical ventilation, who are usually required oxygen therapy after discontinuation of mechanical ventilation.

Detailed Description

Tracheostomy is often performed in patients after or anticipated prolonged mechanical ventilation, who are usually required oxygen therapy after discontinuation of mechanical ventilation.The high-flow tracheal (HFT) oxygen therapy in tracheostomized patients has been shown that can improve oxygenation,but can not induce positive end-expiratory pressure and elevation of end-expiratory lung volume. A modified HFT system by increasing expiratory resistance might induce PEEP and consequently elevate EELV.

Study Timeline

• Study Start: 2017-07-01
• Status Verified: 2017-08
• Study First Submitted: 2017-08-07
• Study First Submitted QC: 2017-08-08
• Study First Posted: 2017-08-10
• Primary Completion: 2017-09-15
• Study Completion: 2018-02-05
• Last Update Submitted: 2018-02-09
• Last Update Posted: 2018-02-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• The tracheostomized patient requiring the convenient oxygen therapy.

Exclusion Criteria

• Under 18 years;
• history of esophageal, gastric or lung surgery;
• The contraindication of using EIT (pacemaker, defibrillator, and implantable pumps).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
The modified HFT	The modified HFT	The high-flow oxygen was delivered via tracheostomy using a modified HFT.

Primary Outcome Measures

Name	Time	Method
The mean end expiratory pressure.	the last 1 minutes of steady breathing during the standard or modified HFT.	The patients was delivering the high flow oxygen via the standard and modified HFT interface for 20 minutes.

Secondary Outcome Measures

Name	Time	Method
Changes in global and regional EELV	the last 1 minutes of steady breathing during the standard or modified HFT.	The Electrical impedance tomography (EIT) was applied in monitoring the change of EELV at the bedside.

Trial Locations

Locations (1)

Jian-Xin Zhou; 🇨🇳 Beijing, Beijing, China