Effects of a combination treatment using probiotics and methotrexate (MTX) in patients with rheumatoid arthritis
Not Applicable
- Conditions
- rheumatoid arthritis
- Registration Number
- JPRN-UMIN000004052
- Lead Sponsor
- Center for Rheumatic Diseases,Yokohama City University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
1.Patients with allergy to milk or foods which contain lactobacillus 2.Patients with critical complications in heart, kidney, liver, and blood disorder 3.Patients treated with biologics 4.Patients considered to be ineligible by the responsible researcher or assigned researcher
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of DAS28 score before administration, and at 1, 4, 12, 24 weeks after administration
- Secondary Outcome Measures
Name Time Method Improvement of mHAQ and VAS before administration, and at 1, 4, 12, 24 weeks after administration Investigation of adverse events, clinical examination values, and the titer of anti-E-coli antibody