The Effects of Tourniquet Use in Total Knee Arthroplasty: A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Blood Loss
- Sponsor
- Peking University People's Hospital
- Enrollment
- 50
- Primary Endpoint
- Intraoperative blood loss
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Tourniquets are still widely used in total knee arthroplasty, but are associated with several adverse effects. Most of previous studies did not randomize the participants so the baseline difference of the patients might have influenced the outcome. Therefore, investigators conducted a randomized controlled trial, in which all the patients received staged bilateral TKA with two different durations of tourniquet use. Investigators aimed to quantify the effect of tourniquet use on reducing blood loss and to evaluate the impact of tourniquet use on functional and clinical outcome.
Detailed Description
Fifty participants who underwent staged bilateral TKA were recruited in this study. On one side, the tourniquet was inflated immediately before incision and deflated after the hardening of the cement. On the other side the tourniquet was inflated immediately before cement application and deflated after its hardening. Blood loss, operating time, transfusion rate, postoperative pain, limb swelling, deep vein thrombosis (DVT) incidence and clinical outcomes were monitored for comparison.
Investigators
Wang Kai
resident
Peking University People's Hospital
Eligibility Criteria
Inclusion Criteria
- •patients aged 50 years or over
- •classified as American Society of Anesthesiologists ASA 1-2.
Exclusion Criteria
- •coagulopathy,
- •uncontrolled hypertension,
- •peripheral vascular disease and
- •patients with BMI≥35
Outcomes
Primary Outcomes
Intraoperative blood loss
Time Frame: within operation
Secondary Outcomes
- Thigh pain measured by Visual Analogue Scale/Score (VAS)(1 day, 2 day, 1 week, 2 week and 6 week after surgery)
- Thigh swelling measured by circumference 10 cm proximal to the patella(1 day, 2 day, 1week, 2 week and 6 week after surgery)
- Postoperative blood loss measured by drainage volume(1 day and 2 day after surgery)