Nefopam as a Multimodal Analgesia for Video-assisted Thoracoscopic Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Pain after 12 hour of surgery
研究概览
简要总结
Acute postoperative pain after video-assisted thoracoscopic surgery is very severe. Because pain after thoracic surgery prevents early recovery, and increases postoperative complications, its is important to prevent pain after video-assisted thoracoscopic surgery. In the present study, we will evaluate whether nefopam reduces pain after video-assisted thoracoscopic surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient scheduled for elective video-assisted thoracoscopic surgery
- •American Society of Anesthesiologists physical grade I, II, III
- •patient aged from 18 years old
排除标准
- •history of allergy in nonsteroidal anti-inflammatory drugs, or nefopam
- •renal insufficiency
- •liver insufficiency
- •myocardial infarction
- •pregnant and lactating women at the time of surgery
- •patient who did not consent to the use of patient-controlled analgesia
研究组 & 干预措施
nefopam group
Intravenous nefopam 20 mg will be administered twice, immediately after induction of anesthesia and at the end of surgery.
干预措施: Nefopam (Drug)
结局指标
主要结局
Pain after 12 hour of surgery
时间窗: 12 hours after surgery.
Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
Pain after 6 hour of surgery
时间窗: 6 hours hours after surgery.
Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
Pain after 1 hour of surgery
时间窗: 1 hour after surgery.
Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
Pain after 24 hour of surgery
时间窗: 24 hours after surgery.
Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
次要结局
- Rescue analgesics(24 hours after surgery.)
- Patient-controlled analgesia use(24 hours after surgery)
研究者
Eunah Cho, MD
Assistant Professor
Kangbuk Samsung Hospital