Study on Patients With Rasmussen Encephalitis Treated With Adalimumab: Efficacy and Tolerance in the Short and Long Term
- Conditions
- Rasmussen Encephalitis
- Registration Number
- NCT04003922
- Lead Sponsor
- Assistance Publique Hopitaux De Marseille
- Brief Summary
Since the initial study of cases reported between 2009 and 2015, adalimumab has become in France the immunomodulatory reference treatment used after failure of corticosteroids and immunoglobulins before a possible recourse to the hemispherotomy. This observational study is intended to document the long-term efficacy and safety of Adalimumab therapy in patients with Rasmussen encephalitis.
- Detailed Description
Rasmussen Encephalitis (ER) is a particularly severe chronic inflammatory brain disorder resulting in the progressive destruction of a hemisphere. It is a rare disease although at present no precise prevalence is available. It begins preferentially in children.
This inflammatory process is accompanied by a progressive loss of function of the affected hemisphere, associated with a pharmaco-resistant partial epilepsy. The diagnosis is based on a bundle of clinical, radiological and electroencephalographic arguments. CSF analysis directs diagnosis in 50% of cases.
No anti-epileptic treatment can stop seizures. Only hemispherotomy (surgical disconnection of a cerebral hemisphere) allows it but it is associated with definitive motor and cognitive deficits.
Over the last 20 years, new therapeutic trials have focused on immuno-modulatory treatments targeted at the T-lymphocyte pathway, including tacrolimus. Although they seem to be more effective than immunoglobulins or corticosteroids, it remains transient. In addition, the number of published cases is low. In this context, starting in 2009, it has been proposed to use adalimumab (Ab anti TNF) based on:
* 1 / study of a case index
* 2 / knowledge of the pathophysiology of Rasmussen Encephalitis. To date, very few data provide precise information on the efficacy or tolerance of the use of this product in the longer term. This information is essential to confirm the place of adalimumab in the therapeutic arsenal against Rasmussen encephalitis.
Thus, in the continuation of the work carried out previously (French study on the cases between 2009 and 2015), the aim of this research projet is to complete the follow-up of the patients who previously took part in in the first study and to establish the follow-up of the patients treated by adalimumab since then.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 40
- Confirmed diagnosis of Rasmussen Encephalitis
- Patient aged more than 2 years
- Compliant treatment with adalimumab
- Patient with a differential diagnosis
- Patient suffering from Rassmussen Encephalitis but not treated with adalimumab
- Patient who has not signed the informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Efficiency of the treatment measured by the reduction of the number of epileptic seizures 5 years The change of epileptic seizures (Will be considered as a responder patient any patient with a 50% decrease in the number of seizures between the time of inclusion and 6 months after the start of treatment). This response to treatment is re-evaluated at 12 months then every 6 months for 5 years.
Efficiency of the treatment measured by the stability if the cognitive assessment 6 months Stability of the cognitive assessment: variation of less than 10 points on each of the different composite indices (QIT, ICV, IRF, IMT, IVT) of age-appropriate Weschler scales, between two cognitive assessments of 6 months.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (16)
Chru de Lille
🇫🇷Lille, France
Hospices Civils de Lyon
🇫🇷Lyon, France
Chu Brest
🇫🇷Brest, France
Chu de Bordeaux
🇫🇷Bordeaux, France
Chu Limoges
🇫🇷Limoges, France
Service Neuropédiatrie
🇫🇷Marseille, France
Chu Necker Ap-Hp
🇫🇷Paris, France
Chu Montpellier
🇫🇷Montpellier, France
Chu de Nancy
🇫🇷Nancy, France
Chu Pitie Salpietriere Ap-Hp
🇫🇷Paris, France
Chu Robert Debre
🇫🇷Paris, France
Fondation Adolphe de Rothshild
🇫🇷Paris, France
Chu de Rennes
🇫🇷Rennes, France
Chru de Tours
🇫🇷Tours, France
Chu Toulouse
🇫🇷Toulouse, France
Chu Strasbourg
🇫🇷Strasbourg, France