Long-term Outcomes of Active Vaccination Against de Novo Hepatitis B Among Pediatric Recipients of Living Donor Liver Transplantations With Anti-HBc (+) Grafts
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 204
- 主要终点
- Long-term survival in pediatric recipients of living donor liver transplantations with anti-HBc (+) grafts
研究概览
简要总结
The goal of this observational study is to compare in anti-HBc (+) grafts/ anti-HBc (-) grafts. The main question it aims to answer is the long-term efficacy of active vaccination and graft/patient outcomes of anti-HBc (+) grafts have yet to be comprehensively investigated. Researchers will compare anti-HBc (+) grafts/ anti-HBc (-) to see if it would affect the long-term survival.
详细描述
A particular strength of the present study is in the inclusion of a consecutive cohort of pediatric LDLT recipients with long-term details of follow-up, although there are several limitations. First, this was a retrospective study conducted at a single medical center. Second, the HBV prophylaxis changed from lamivudine to entecavir in 2008, therefore investigators were unable to evaluate the risk of developing lamivudine resistance. In addition, the DNA level data for the donor and graft tissues were lacking. Lastly, this study was conducted in an area with a high prevalence of anti-HBc positivity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 4 Months 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •consecutive pediatric LDLT recipients.
排除标准
- •Adult LDLT recipients
结局指标
主要结局
Long-term survival in pediatric recipients of living donor liver transplantations with anti-HBc (+) grafts
时间窗: Feb. 2002-Feb.2016
Investigation of the Long-term survival in pediatric recipients of living donor liver transplantations with anti-HBc (+) grafts
次要结局
未报告次要终点
研究者
Chih-Che Lin
Professor
Chang Gung Memorial Hospital