Rapidness of Analgesic effect of sucrose

Not yet recruiting

Conditions: Illness, unspecified,

Registration Number: CTRI/2019/12/022572

Lead Sponsor: Pramukhswami Medical College

Brief Summary: International Association for the Study of Pain defines pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage [1]. Repeated painful exposures can have deleterious consequences. These consequences include altered pain sensitivity (which may last into adolescence) and permanent neuroanatomic and behavioral abnormalities, as found in animal studies.

Neonates admitted to NICU receive multiple painful procedures as a part of their medical management and care. They are frequently exposed to repeated procedural pain and experience significant stress during critical period of physiological vulnerability and rapid neurological development.

Neonates and more predominantly preterm neonates have the nociceptive circuitry but this system is functionally immature [2,3]. Cutaneous nociceptors fields are large in the neonates, and peripheral sensory fibers are extremely sensitive to tissue injury and have reduced peak firing frequencies.[2-5] They also have low discriminatory ability to discriminate between noxious and non-noxious stimuli.[6,7] Subpalate Neurons which are a important of Thalamic efferent circuitry connecting thalamus to cerebral cortex and Preoligiodendrocytes which are precursors to myelin producing oligodendrocytes are particularly vulnerable to pain, and may undergo apoptosis following exictotoxic free radical or inflammatory damage.[8,9] Multiple studies have shown the benefits of sucrose on neonatal pain reduction.[10-12] However, ideal sucrose administration time before the pain stimuli has not been studied adequately.

As per previous study in our instutite pain was reduce if sucrose given before 30 seconds,hence we belived that even sucrose given before 15 second of heel prick it would reduce pain so we want to know that sucrose <15 second before the procedure reduces the neonatal pain by randomized control trial to compare effect of time after sucrose administration on preterm neonatal pain control during heel prick.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 200

Inclusion Criteria

All neonates with gestation from 28 weeks to 36 weeks.

Exclusion Criteria

Neonates on invasive ventilator (non cpap) Clinically evident abnormal neurological signs have received analgesic or sedative in last 24 hours.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PIPP Score at the end of procedure	PIPP Score at the end of procedure

Secondary Outcome Measures

Name	Time	Method

Trial Locations

Locations (1): Neonatal Intensive Care Unit, Shree Krishna Hospital
🇮🇳
Anand, GUJARAT, India
Neonatal Intensive Care Unit, Shree Krishna Hospital
🇮🇳Anand, GUJARAT, India
Dr Dipen Patel
Principal investigator
9825331453
dipen_patel258@yahoo.co.in