Evaluation of Contralateral R1 Component of the Blink Reflex in Patients With Amyotrophic Lateral Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Presence of a contralateral R1 component on blink reflex evaluation.
研究概览
简要总结
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Electroneuromyography is an important tool for the diagnosis. Previous studies have shown that different components of the blink reflex, such as the latencies of homo- and contralateral R2 responses can be affected. Studies have found that a contralateral R1 component can appear in neurological diseases with affection of the central nervous system especially upper motor neuron, such as HTLV1 infection. Thus, you aim to determine if a contralateral R1 component could be present in ALS.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For patients
- •Aged 18 to 99 years old
- •Referred for suspected motor neuromuscular disease
- •Collection of non-opposition
- •For healthy subjects:
- •Aged 18 to 99 years old
- •Absence of any neurological pathology
- •Collection of non-opposition
排除标准
- •Previous damage linked to another cause of the cranial nerves
- •Prior brainstem lesions
- •Persons deprived of liberty by a judicial or administrative decision
- •Patient under judicial protection, unable to express consent
结局指标
主要结局
Presence of a contralateral R1 component on blink reflex evaluation.
时间窗: Day 1
A blink reflex evaluation will be performed in all subjects : Blink reflex will be recorded with surface electrodes placed medially over the lower part of the eyelid, on the orbicularis oculi muscle, with a reference electrode 2 cm laterally. Stimuli will be delivered to the supraorbital nerve by surface electrodes with an intensity required to generate a consistent homolateral R1 response. A contralateral R1 component will be defined as an early compound muscle action potential recorded in the contralateral orbicularis oculi muscle.
次要结局
未报告次要终点