Pregnancy Rate by HCG Administration Versus Urinary LH Surge Method in Patients Undergoing IUI
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 86
- 试验地点
- 1
- 主要终点
- pregnancy rate
研究概览
简要总结
To compare pregnancy rate by Human Chorionic Gonadotropin (HCG) administration and urinary Luteinizing Hormone (LH) surge method for insemination in patients undergoing Intrauterine Insemination (IUI) at Montaserieh infertility center.
The present study comprised 309 infertile women candidate for IUI, randomly divided into LH surge and HCG groups (assign the number for each patient, odds number for LH and even number for HCG group). All patients were subjected to baseline ultrasound and received clomiphene citrate before undergoing serial transvaginal sonography. LH was measured using LH kit when 2-5 follicles (18-20 mm) appeared in LH surge group, and if positive, IUI was performed after 24 hours. In HCG group, the patients received HCG 1000 units and underwent IUI after 36 hours. The pregnancy rate was then compared in LH and HCG groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 接受健康志愿者
- 是
入选标准
- •infertile women candidate for IUI
排除标准
- •women with negative urinary LH surge which required HCG administration,
- •those with more than 5 follicles who had to use LH kit and not receive HCG to avoid ovarian hyperstimulation.
研究组 & 干预措施
HCG group
HCG group
干预措施: HCG (Drug)
HCG group
HCG group
干预措施: Clomiphene (Drug)
LH group
LH group
干预措施: LH (Drug)
LH group
LH group
干预措施: Clomiphene (Drug)
clomiphene citrate
clomiphene citrate
干预措施: LH (Drug)
clomiphene citrate
clomiphene citrate
干预措施: HCG (Drug)
结局指标
主要结局
pregnancy rate
时间窗: Two weeks after IUI
次要结局
未报告次要终点
研究者
Payam Peymani
Head Of Pharmacoepidemiology Department, Health policy Research Center,Shiraz university of Medical Sciences
Shiraz University of Medical Sciences