Metabolomics of Liver Regeneration Following Partial Hepatectomy in Healthy Living Liver Donors
Completed
- Conditions
- Liver Insufficiency
- Registration Number
- NCT01922323
- Lead Sponsor
- Baylor Research Institute
- Brief Summary
The PI will study metabolism during liver regeneration in living liver donors
- Detailed Description
Samples of blood and urine will be collected from study participants at defined timepoints. The samples will be evaluated to study the metabolism of the regenerating liver after a portion of the liver has been donated from a living donor.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Potential donor must be in excellent medical and psychological health.
- Potential donor must be between the ages of 18 and 60.
- Must have a compatible blood type to the recipient.
- Must have health care coverage for non-donor related health issues that arise post donation
- Recipient and donor must have compatible body size.
- Donors Body Mass Index (BMI) must be less than 30.
- All previous donor abdominal surgeries will be reviewed on a case by case basis by the surgeon.
Exclusion Criteria
-
Positive blood test for Human Immunodeficiency Virus, Hepatitis C virus, Hepatitis B virus
-
The size of the donor liver is not large enough to safely resection and still retain enough volume to function normally after the surgery.
-
Liver biopsy show liver cirrhosis or early stages of HCC.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Characterized Metabolic Changes during liver regeneration one year after donation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Baylor University Medical Center
🇺🇸Dallas, Texas, United States