Electronic Multidrug Blister Packs to Improve Clinical and Humanistic Outcomes in Patients After Hospital Discharge
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Medication Possession Ratio
研究概览
简要总结
The purpose of this study is to determine the benefit of patients using a multidrug blister packs after discharged from an university hospital to their homes.
详细描述
Typical adherence rates for oral prescription medications are approximately 50-76%. Insufficient adherence causes an increase in morbidity, mortality, and costs, and decreases quality of life of patients. Multidrug blister packs are recommended to improve adherence and are widely used in Switzerland. However, evidence is poor and patient-relevant endpoints are seldom measured. This study was designed to compare patient-relevant outcomes in patients with medication repackaged in multidrug blister packs versus patients with medication dispensed in commercially available packages. Adherence of the intervention group will be monitored electronically and feedback will be given to the patients. The intervention will take place in a study pharmacy. Follow-up visits will take place at the study pharmacy at 3, 6, and 12 months for all patients. Study duration will be 12 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age over 18 years
- •Prescription of 4 or more different oral solid drugs
- •Capable to understand german (verbally and written)
- •Capable to give informed consent
- •Insured by a Swiss health insurance
- •Manages his/her pharmacotherapy without external support
- •Obtains his/her medication from a community pharmacy
- •Accepts to use an electronic multidrug blister pack
- •Place of domicile in Basel-Stadt or Basel-Land
排除标准
- •Pregnancy
- •> 2 drugs that cannot be packed into a multidrug blister pack (e.g. fluids)
- •Dementia, or evaluated as cognitively impaired by the responsible nurse
- •Transplanted patient
- •Anticoagulation with oral vitamin K antagonists
- •Has already used a multidrug blister pack of Pharmis or a Medifilm® single dose system
- •is visually impaired (blind)
- •cannot push drugs through a blister
- •refuses to allow contact to his/her regular pharmacy and GP
- •is referred to a nursing home or to rehabilitation or another hospital at discharge
- •is included in other clinical trial
结局指标
主要结局
Medication Possession Ratio
时间窗: 12 months
MPR will be assessed at 3, 6, and 12 months.
Time to rehospitalisation + time to major therapy adjustment
时间窗: 12 months
The outcome measure will be assessed at 3, 6, and 12 months.
次要结局
- Timing and taking adherence according to the electronic monitoring system and through patient self report(12 months)
- Quality of life(12 months)
- Patient satisfaction(12 months)
研究者
Kurt Hersberger
Professor PhD
University Hospital, Basel, Switzerland