Effect of Low Intensity Blood Flow Restriction Training on Lower Extremity Strength and Hypertrophy
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Minnesota
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- One Repetition Maximum
Study Overview
Brief Summary
The particpant will complete baseline testing by measuring subjects' quadriceps muscle thickness (cm) via ultrasound technology, as well as have them complete a one repetition maximum (1RM) test on the leg press machine and an isometric knee extension using a dynamometer - strength measures will be calculated for both right and left legs. After baseline testing, subjects will complete 6 weeks of the testing protocol that will consist of leg press exercises at 30% of their 1RM. Subjects will be randomized to either wear a cuff that partially restricts blood flow to the limb (Study Group), or to wear a cuff that does not restrict blood flow (Control Group). Exercises will be completed 2x/week and will take approximately 10 total minutes (5 for warm up, 5 for testing protocol) per session. After 6 weeks, muscle thickness, leg press 1RM, and quadriceps extension strength will be re-tested and compared to the initial measurements.
Detailed Description
Session 1 - baseline testing
- 5-minute warm-up; 1RM calculation for both right and left legs using a supine leg press machine; isometric quadriceps strength measurement using a dynamometer; muscle thickness measurements of both right and left quadriceps muscle using ultrasound technology.
- After day 1 testing; randomly allocate subjects to either control group or experimental group
Sessions 2-13 - 6 weeks of exercise protocol, 2x/per week
Both the experimental and control groups will complete the same protocol for the entirety of the study:
- 5- minute warm up
- Using a single-leg press exercise machine: Subjects complete the testing protocol with either partial blood flow restriction (cuff inflated to 100-250 mmhg depending on size of person) or no blood flow restriction (placebo inflation) on right limb.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 49 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age 18-49
Exclusion Criteria
- •Hypertensive
- •Recent back or lower extremity injury
- •History of blood clotting
- •Varicose veins
- •Adults lacking the capacity to consent for themselves
Arms & Interventions
Blood flow restriction cuff
This group will receive an active cuff that partially restricts blood flow to the experimental limb.
Intervention: Blood flow restriction cuff (Device)
Blood Flow restriction Cuff-Placebo
This group will wear a placebo cuff, of which will not restrict blood flow at all.
Intervention: Blood Flow restriction Cuff-Placebo (Device)
Outcomes
Primary Outcomes
One Repetition Maximum
Time Frame: 6 weeks
One repetition maximum on the single leg press. Isometric quadriceps extension strength.
Secondary Outcomes
- Quadriceps Muscle Thickness(6 weeks)