Is step initiation during improbable events affected in PD with or without FOG? An explorative study.

Completed

• Conditions: Parkinson's disease; 10028037

• Registration Number: NL-OMON42242
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

• Men/women of age > 60 years
• Can provide written informed consent
• For participants with Parkinson*s disease: Idiopathic Parkinson*s disease, according to the UK Brain Bank Criteria (Hughes et al., 1992)
• For participants with PD and FOG: Presence of FOG (Subjectively: defined as a score of 1 on question *Have you experienced FOG in the past month* from the NFOGQ, and, objectively: objectively measured observed at any time by a neurologist or during previous experiments)
• For both PD groups: Clinically worsened (as measured by UPDRS) during OFF state (Galea et al., 2012)
• Able to walk without an aid, even when off dopaminergic medication

Exclusion Criteria

- Presence of any other neurological disorders such as stroke or epilepsy or psychiatric disease
- Pain, and or major outstanding musculoskeletal/ orthopaedic conditions in their lower limbs or back (pain that prevents independent performance of an activity of daily living)
- Dyslexia (or unable to read and write)
- Visual impairments which would affect seeing the screen in the balance lab
- Uncontrolled diabetes or thyroid problems
- History of severe, frequent headaches
- Dementia (cognitive impairment): TICs-m score of <=27 (Knopman et al., 2010, de Jager et al., 2003, Markopoulou et al., 2014)
- ON-freezing (freezing when on dopaminergic medication) (Espay et al., 2012)
- Depression: GDS-5/15 score of > 4 (Weintraub et al., 2006, D'Ath et al., 1994)
- Patients with deep brain stimulation
- Polineuropathy

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Average Reaction Time: defined as the average time from appearance of the<br /><br>visual stimulus to first unloading of any leg (Creath et al., 2013).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Step Length: defined as the distance from step onset to end of step.<br /><br>- Step Duration: defined as the time from step onset to end of step.<br /><br>- Anticipatory Postural Adjustments: defined as the maximum increase in<br /><br>vertical force directed towards the stepping leg, normalized for body weight<br /><br>and corrected for the amount of loading (Mensink et al., 2014).<br /><br>- Learning Rate: The time taken to reach 95% errorless performance. This will<br /><br>be measured only during training. </p><br>