Evaluation of folliculogenesis in poor responds women after intrauterine injection of autologous platelet-rich plasma

Phase 1

Recruiting

Conditions: Patients with poor ovarian response.

Registration Number: IRCT20220510054808N1

Lead Sponsor: Ghoum University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 32

Inclusion Criteria

previous IVF (In vitro fertilisation) that resulted in the recovery of less than three eggs or an abnormal ovarian reserve test involving less than five AFCs (Antral follicle count )
All women have a regular menstrual cycle.
the level of follicles or AMH (Antimullerian Hormone) should be less than 1.1 ng / ml.
those under 40 years of age.

Exclusion Criteria

Autoimmune disorders, sexually transmitted diseases, infectious diseases, infertility / tubal factor tube obstruction, chronic inflammatory diseases, endometriosis, chronic endometritis, and endocrine disorders such as thyroid dysfunction.
anemia, thrombophilic disorders, current cancer diagnosis, or medical history of cancer

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Platelet-enriched plasma cell count. Timepoint: After plasma preparation. Method of measurement: With cell counting machine.

Secondary Outcome Measures

Name	Time	Method
Expression of folliculogenesis genes. Timepoint: After collecting granulosa cells on the day of oocyte someone both the control group and the treated group. Method of measurement: Real time PCR.;Hormone secretion levels. Timepoint: At monthly intervals after the puncture and before the puncture. Method of measurement: Immunoassay.;Antral follicle count. Timepoint: At monthly intervals after the puncture and before the puncture. Method of measurement: sonography.;The quality of oocytes. Timepoint: after puncture. Method of measurement: with stereomicroscope.;Oocyte and embryo quality. Timepoint: after puncture. Method of measurement: With a stereomicroscope.;Spontaneous fertility. Timepoint: 14 days after embryo transfer. Method of measurement: Pregnancy test and sonography.