A clinical trial to study the effects of two types of dressing, Limited access dressing and conventional dressing in patients with Non healing chronic ulcers.
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Non healing chronic ulcers
- Registration Number
- CTRI/2015/01/005419
- Lead Sponsor
- Manipal univeristy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 84
Inclusion Criteria
Non diabetic chronic ulcers
Exclusion Criteria
Patients with collagen disorders, Leprosy patients, Pregnant women, Liver cirrhosis, HIV +ve patients.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Collagen content (Hydroxyproline) in the granulation tissueTimepoint: After 10 days of treatment
- Secondary Outcome Measures
Name Time Method hexosamine, total protein, and antioxidants [reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione s-transferase (GST), catalase (CAT), thiol], wound surface pH, matrix metalloproteinase-2 (MMP-2), and oxidative biomarker malondialdhyde (MDA) were measured in the granulation tissue. Histopathologically, necrotic tissue, amount of inflammatory infiltrate, angiogenesis and extracellular matrix deposition (ECM) were studied to determine wound healing.Timepoint: After 10 days of treatment