Effect of sodium-dependent glucose co-transporter 2(SGLT2) inhibitors on muscle strength in patients with type 2 diabetes mellitus
- Conditions
- type 2 diabetes mellitus
- Registration Number
- JPRN-UMIN000018367
- Lead Sponsor
- Ise Red Cross Hospital Department of Metabolic Diseases
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 30
Not provided
1) Type 1 diabetes 2) Had ketosis or coma within 6 month 3) Secondary diabetes 4) Patients receiving GLP-1 analogue therapy 5) Poor-controlled diabetes (HbA1c>=10.0 % or fasting blood glucose levels>=250mg/dl) 6) History of stroke, acute coronary syndrome or any cardiovascular diseases needed for inpatient-treatments within 6 months 7) Patients with complication of severe hepatic disorder, e.g., hepatocirrhosis 8) Renal insufficiency: Ccr<45 mL/min/1.73m2 9) Patients who have serious complication of gastrointestinal disorders or who underwent a surgical operation that is known to affect the absorption of a drug by digestive tract 10) Patients who are susceptible to dehydration 11) Patients who is a chronic heavy drinker 12) Patients with history of urinary infection or genital infection disease 13) Malignancies or other diseases with poor prognosis 14) Pregnant 15) Subjects whose doctor in charge do not agree to join the trial
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method grip strength, quadriceps muscle strength
- Secondary Outcome Measures
Name Time Method abdominal fat free area and visceral fat area, Hemoglobin A1C levels, pre/postprandial blood glucose levels, BMI