A Randomized comparative Study To Assess Post Extubation Sore Throat using Preoperative Nebulization with Magnesium Sulphate versus Lignocaine in Patients undergoing Laparoscopic Surgeries at SMS Medical College, Jaipur.
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- 1.To assess and compare the proportion of sore throat ( swallowing and rest) between two groups after extubation till 48 hours.
研究概览
简要总结
This prospective ,randomized comparative study is being conducted at S.M.S Medical College and Hospital,Jaipur to assess the post extubation sore throat using preoperative nebulization with 4ml of 6.25 percentage of Magnesium Sulphate and 4ml of 2 percentage Lignocaine in patients undergoing laparaoscopic surgeries.A total of 150 patients will be enrolled and randomized into two equal groups(Magnesium Sulphate group and Lignocaine group).Parameters such as postoperative sore throat at rest and swallowing,Hoarseness of voice ,Cough ,Adverse effects (nausea ,vomiting,hypotension and respiratory depression)and Intraoperative Haemodynamic parameters will be recorded at predefined intervals.The aim is to identify the group in which duration of postoperative sore throat at rest and swallowing is less compared to another group and ensuring haemodynamic stability with minimal adverse effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients undergoing elective laparoscopic surgeries under General Anaesthesia.
- •2.Patients giving written informed consent 3.Patients having American Society of Anesthesiologist (ASA) physical status 1 and
- •4.Patients of age more than 18 years.
- •5.Patients with Mallampati grade 1 or 2.
排除标准
- •1.Patient who is part of any other study.
- •2.Patients with upper respiratory tract infection.
- •3.Patients with nasogastric tube and any nasal or throat pack require intraoperatively.
- •4.Allergy to study drugs.
结局指标
主要结局
1.To assess and compare the proportion of sore throat ( swallowing and rest) between two groups after extubation till 48 hours.
时间窗: 1.Postoperative sore throat will be checked ( swallowing and rest) between two groups at 2 hours,8hours,24hours and 48hours after extubation.
次要结局
- 1.To assess & compare the proportion of hoarseness of voice & cough between two groups after extubation till 48 hours.(2.To assess & compare haemodynamic parameters-Heart rate,Systolic blood pressure,Diastolic blood pressure,Mean arterial pressure from induction to extubation at every 10 minutes interval.)
研究者
Dr Arunkumar
SMS Medical College ,Jaipur