Evaluation of Immune Signaling Networks in Healthy Human Volunteers
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- Numerical and functional changes of circulating immune cells over time in healthy individuals
Study Overview
Brief Summary
The purpose of this study is to better understand whether and to what extent the activity of immune cells in blood varies over time under normal conditions as assessed in healthy subjects. Results of this study will provide the foundation for helping us evaluate changes in immune cell activities in response to surgery and drugs used in anesthesia. The overall purpose of our research is to understand immune health in the context of anesthesia and surgery.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Good general health
Exclusion Criteria
- •Recent cold or flu
- •Chronic use of medications affecting the immune system
- •Chronic illness
- •Smoking habit
- •History of drug abuse
- •Current recreational drug use
Outcomes
Primary Outcomes
Numerical and functional changes of circulating immune cells over time in healthy individuals
Time Frame: Day 1, Day 2, Day 7, Day 28
This is an exploratory study. Numerical and functional (phosphorylation of signaling molecules and transcription factors) behavior of all circulating immune cells will be captured. Blood specimens collected at referenced time points will be analyzed with mass cytometry.
Secondary Outcomes
No secondary outcomes reported
Investigators
Martin Angst
Professor of Anesthesia
Stanford University