IV Labetalol Vs Oral Nifedipine in control of severe hypertension in pregnancy
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Pregnancy with PreEclampsia
- Registration Number
- CTRI/2017/10/009977
- Lead Sponsor
- Government Siddhartha Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
All antenatal women of gestational age >28 weeks with severe hypertension
with systolic blood pressure (BP) of 160 mm Hg or higher and/or diastolic BP
of 110 mm Hg or higher on 2 separate occasions 30 minutes apart in lateral
recumbent position
Exclusion Criteria
1. Patients with history of cardiac disease
2. Patients with history of bronchial asthma
3. Patients with history of haematological disorder
4. Patients with history of allergy to labetalol or nifedipine
5. Patients with liver disorders
6. Maternal heart rate <50bpm or >120 bpm
7. Patients with history of exposure to any anti-hypertensive medications in the
past 24 hours
8. Patients with chronic hypertension
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The time taken in minutes,by either drug to achieve the target blood pressure <br/ ><br>of systolic BP 150mmHg and/or diastolic BP 110mmHg.Timepoint: Mean time taken to achieve target blood pressures in a set study population for a period of two years
- Secondary Outcome Measures
Name Time Method The number of doses required <br/ ><br>Adverse effects <br/ ><br>Maternal and perinatal oucomeTimepoint: mean number of doses required, adverse effects and maternal and perinatal outcome in a set study population at the end of 2 years