Comparative study of Bupropion and Citalopram in response rate for patients with Major Depressive Disorder
Phase 3
Recruiting
- Conditions
- Major Depressive Disorder.Major depressive disorder, single episode
- Registration Number
- IRCT20190706044121N1
- Lead Sponsor
- Gorgan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 104
Inclusion Criteria
Diagnosis of major depressive disorder based on structured clinical interview and DSM-5
Older than 30 years old
Sufficient fluency in Farsi and literacy reading and writing
lack of any comorbid disorder, especially anxiety disorders and substance use
retarded or normal psychomotor
Exclusion Criteria
previous appropriate response to a certain antidepressants
taking antidepressants when visiting
using BZDs, mood stablizers or antipsychotics
concurrent psychotherapy
medical conditions including cardiovascular disease
suicidal ideations and psychotic symptoms
need to admit to the mental ward
agitation or mixed mood symptoms
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Objective treatment response. Timepoint: at baseline and 2 and 4 weeks after pharmacotherapy. Method of measurement: Reduction of more than 50% of base score on Hamilton Depression Rating Scale (HAM-D).;Subjective treatment response. Timepoint: at baseline and after 2 and 4 weeks of pharmacotherapy. Method of measurement: reduction of baseline score in Cognitive Triad Inventory (TCI).
- Secondary Outcome Measures
Name Time Method