NCT00170989已完成3 期
Comparison of the Combination of Valsartan 320 mg Plus Hydrochlorothiazide 12.5 mg and Valsartan 320 mg Plus Hydrochlorothiazide 25 mg to Valsartan 320 mg in Mild to Moderate Hypertensive Patients Not Adequately Controlled With Valsartan 320 mg
适应症
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- Novartis
- 入组人数
- 2,714
- 试验地点
- 2
- 主要终点
- Change from baseline in diastolic blood pressure from baseline after 8 weeks
研究概览
简要总结
This study will test the effectiveness and safety of a combination treatment in patients whose blood pressure is not controlled with a single medication.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with mild to moderate hypertension
排除标准
- •Severe hypertension
- •History of stroke, myocardial infarction, heart failure, chest pain, abnormal heart rhythm
- •Liver, kidney, or pancreas disease
- •Insulin dependent diabetes
- •Allergy to certain medications used to treat high blood pressure
- •Other protocol-defined exclusion criteria may apply.
结局指标
主要结局
Change from baseline in diastolic blood pressure from baseline after 8 weeks
次要结局
- Change from baseline in systolic blood pressure from baseline after 8 weeks
- Change from baseline in standing systolic and diastolic blood pressure after 8 weeks
- Diastolic blood pressure less than 90 mmHg or at least a 10 mmHg decrease in diastolic pressure after 8 weeks
- Diastolic blood pressure less than 90 mmHg after 8 weeks
- Adverse events and serious adverse events at 8 weeks
研究者
研究点 (2)
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